Date of download: 11/12/2017 Copyright © ASME. All rights reserved. Evaluating the Effect of Sinex® (0.05% Oxymetazoline) Nasal Spray on Reduction of Nasal Congestion Using Computational Fluid Dynamics J Biomech Eng. 2015;137(8):081011-081011-9. doi:10.1115/1.4030825 Figure Legend: Nasal passages (darker gray region) reconstructed from MRI slices using Simpleware. Face included for illustrative purposes only.

Date of download: 11/12/2017 Copyright © ASME. All rights reserved. Evaluating the Effect of Sinex® (0.05% Oxymetazoline) Nasal Spray on Reduction of Nasal Congestion Using Computational Fluid Dynamics J Biomech Eng. 2015;137(8):081011-081011-9. doi:10.1115/1.4030825 Figure Legend: Calculation of nasal resistance; steeper slopes indicate higher nasal resistance

Date of download: 11/12/2017 Copyright © ASME. All rights reserved. Evaluating the Effect of Sinex® (0.05% Oxymetazoline) Nasal Spray on Reduction of Nasal Congestion Using Computational Fluid Dynamics J Biomech Eng. 2015;137(8):081011-081011-9. doi:10.1115/1.4030825 Figure Legend: 3D CAD models reconstructed from MRI slices of subject NN (Sinex®) at the three time points qualitatively show an increase in flow volume after treatment

Date of download: 11/12/2017 Copyright © ASME. All rights reserved. Evaluating the Effect of Sinex® (0.05% Oxymetazoline) Nasal Spray on Reduction of Nasal Congestion Using Computational Fluid Dynamics J Biomech Eng. 2015;137(8):081011-081011-9. doi:10.1115/1.4030825 Figure Legend: Flow path lines in nasal passages of subject NN (Sinex®) at three time points: (a) predose, (b) 8 hr post-treatment, and (c) 12 hr post-treatment. Dashed box showing location of nasal valve in predose image.

Date of download: 11/12/2017 Copyright © ASME. All rights reserved. Evaluating the Effect of Sinex® (0.05% Oxymetazoline) Nasal Spray on Reduction of Nasal Congestion Using Computational Fluid Dynamics J Biomech Eng. 2015;137(8):081011-081011-9. doi:10.1115/1.4030825 Figure Legend: Nasal passage anatomy (coronal view) SM: superior meatus; MM: medial meatus; IM: inferior meatus

Date of download: 11/12/2017 Copyright © ASME. All rights reserved. Evaluating the Effect of Sinex® (0.05% Oxymetazoline) Nasal Spray on Reduction of Nasal Congestion Using Computational Fluid Dynamics J Biomech Eng. 2015;137(8):081011-081011-9. doi:10.1115/1.4030825 Figure Legend: Scatter plots for percentage reduction of nasal resistance: (a) after 8 hr; (b) after 12 hr

Date of download: 11/12/2017 Copyright © ASME. All rights reserved. Evaluating the Effect of Sinex® (0.05% Oxymetazoline) Nasal Spray on Reduction of Nasal Congestion Using Computational Fluid Dynamics J Biomech Eng. 2015;137(8):081011-081011-9. doi:10.1115/1.4030825 Figure Legend: Chart of Relative Risk (RR) reductions of 50% or more at both time points