http://creativecommons.org/licenses/by-sa/2.0/ Lecture 2.1

Biology Review A Question and Answer Session First & Last Name February X, 2005 Biology Review A Question and Answer Session About the Biological Concepts Covered in this Workshop Lecture 2.1 (c) 2005 CGDN

Biological Concept Map An exercise to get us started.... Take out the workshop schedule provided as part of the handout for Lecture 2.1 Can you identify the major biological concepts covered in each of the workshop sessions? Make some notes on the schedule about any questions you have about these biological concepts Lecture 2.1

Here’s an Example of a Biological Concept Map for Week 1… How does sequence similarity imply function? What kinds of large scale data analyses are needed? Why is evolution so important? What is phylogeny? How do we define data types for complex biological data? What does knowing the sequence of a genome enable? Biology has an exception to every rule How does sequencing technology work? What are genome sequences? What are genes? Lecture 2.1

Here’s an Example of a Biological Concept Map for Week 2… What is transcription? How are genes expressed? What about populations? What can gene expression data tell us? What about variations? What is the difference between the genome in GenBank and my genome? Can we draw all the connections that happen in a cell? Can we make models of cells? What is translation? What kinds of questions can you ask with the genome of an organism? Why is protein structure so important? What are RNA genes? How does RNA fit into the Central Dogma of Biology? Lecture 2.1

What is transcription? Lecture 2.1 Picture from: http://vcell.ndsu.nodak.edu/~christjo/vcell/animationSite/transcription/movie.htm Lecture 2.1

What is a transcription factor? Lecture 2.1

How do microarrays work? Lecture 2.1

What is translation? Lecture 2.1 Picture from: http://vcell.ndsu.nodak.edu/~christjo/vcell/animationSite/translation/movie.html Lecture 2.1

Why is protein structure so important? Picture from: http://www.ornl.gov/hgmis Lecture 2.1

What is cloning? Picture from: http://www.ornl.gov/hgmis Lecture 2.1

How does sequencing work? Lecture 2.1

What does knowing the sequence of a genome enable? Picture from: http://www.ornl.gov/hgmis Lecture 2.1

What kinds of questions can you ask with the genome of an organism? Picture from: http://www.ornl.gov/hgmis Lecture 2.1

What about variations in individuals? Picture from: http://www.ornl.gov/hgmis Lecture 2.1

Can we make models of cells? Picture from: http://vcell.ndsu.nodak.edu/ Lecture 2.1

The wired cell … will it exist? Picture from: http://www.ornl.gov/hgmis Lecture 2.1

Is Systems Biology the answer? Lecture 2.1

Where does ethics fit? Lecture 2.1 Picture from: http://www.ornl.gov/hgmis Lecture 2.1

Credits Many of the images in this presentation are a credit to the U.S. Department of Energy Human Genome Program, who makes the images they create freely available on the web. Many kudos! Lecture 2.1