Table II: AED in “good" and "bad" outcome groups Therapeutic changes in patients on antiepileptic polytherapy: looking for the "winner" combination Hernando V, Huertas N, Juarez N, Diez A Hospital Universitario Severo Ochoa, Leganes, Spain  Keywords: epilepsy, antiepileptic drug polytherapy Introduction: To analyze the clinical outcome of different antiepileptic drugs (AED) combinations in patients taking at least three AED.  Methods: Review of the neurologic history of the last 668 patients attended in our Epilepsy Outpatient Clinic. Figures 1 and 2, table I: epidemiologic data Table II: AED in “good" and "bad" outcome groups Results: From 42 patients on three or more AED (figures 1 and 2, table I), we reviewed 151 AED combinations. Number of combined AED: 3,3 (2-6). Outcomes: improvement (seizure frequency): 54 combinations (35,8 %, the "good outcome" group, with follow up longer of 6 months in more than 90 %), in 46 (30,5 %) seizure frequency did not change, in 29 (19,2 %) increased the frequency (the "bad outcome" group), in 22 (14,6%) the treatment failed due to adverse events. Reduction of seizure frequency ("good outcome" group): 81,2 % (reduction over 50 % of seizure frequency: 81,8 %), in 8 combinations (5,3 %) seizure freedom was obtained. We did not find statistical differences in the distribution of AED in both groups (“good" and "bad" outcomes): p=0,269. Lamotrigine was present in 10,29 % of the "good outcome" and in 5,56 % of "bad outcome" combinations (p=0,195, table II), this difference is not related to the synergy of combination of lamotrigine and valproic acid (associated in 33 % of combinations in the "good outcome" and in 40 % in the "bad outcome" group). Conclusion: Our data support the idea, less pessimistic than classically accepted, that active intervention in AED polytherapy can lead to good outcomes. Lamotrigine is slightly more present in combinations with good outcome, but in our series we find only a tendency.

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