C. Neuronal activity of cortical and thalamic neurons becomes synchronized during a primary generalized seizure. The depolarization is dependent on conductances in AMPA-type glutamate receptor-channels and T-type voltage-gated Ca2+ channels. The repolarization is caused by GABA-mediated inhibition as well as voltage- and calcium-dependent K+ conductances (g K). (Reproduced, with permission, from Lothman 1993a.) Source: Seizures and Epilepsy, Principles of Neural Science, Fifth Editon Citation: Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ, Mack S. Principles of Neural Science, Fifth Editon; 2012 Available at: http://neurology.mhmedical.com/DownloadImage.aspx?image=/data/books/1049/kan_ch50_f012.png&sec=59145717&BookID=1049&ChapterSecID=59138682&imagename= Accessed: November 12, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved