Jason P. Hodde, Mark D. Suckow, Chad Johnson, Eric Rodenberg, Rae D

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Histological and adhesiogenic characterization of the Zenapro Hybrid Hernia Repair Device Jason P. Hodde, Mark D. Suckow, Chad Johnson, Eric Rodenberg, Rae D. Ritchie International Journal of Surgery Open Volume 5, Pages 27-32 (January 2016) DOI: 10.1016/j.ijso.2016.09.005 Copyright © 2016 The Authors Terms and Conditions

Fig. 1 Tissue response to Zenapro in the rat after 3 weeks. Histological (H&E) analysis demonstrates significant fibrovascular tissue ingrowth, minimal inflammation immediately adjacent to the propylene fibers, and remnant SIS undergoing active remodeling. Bar = 100 µm. International Journal of Surgery Open 2016 5, 27-32DOI: (10.1016/j.ijso.2016.09.005) Copyright © 2016 The Authors Terms and Conditions

Fig. 2 Tissue response to Ventralight ST in the rat after 3 weeks. Histological (H&E) analysis shows inflammatory cells directed toward the adhesion-resistant coating as well as significant fibrovascular tissue deposition around the implant. Bar = 100 µm. International Journal of Surgery Open 2016 5, 27-32DOI: (10.1016/j.ijso.2016.09.005) Copyright © 2016 The Authors Terms and Conditions

Fig. 3 Tissue response to Prolene in the rat after 3 weeks. Histology (H&E) shows only minimal amounts of tissue deposition with some inflammation immediately around the polypropylene fibers. Bar = 100 µm. International Journal of Surgery Open 2016 5, 27-32DOI: (10.1016/j.ijso.2016.09.005) Copyright © 2016 The Authors Terms and Conditions

Fig. 4 Direct histological comparison of collagen deposition in the rat. Trichrome staining suggests that collagen accumulation was greatest for the Zenapro implants (a) as compared to either the Ventralight ST (b) or Prolene implants (c). Bars = 100 µm. International Journal of Surgery Open 2016 5, 27-32DOI: (10.1016/j.ijso.2016.09.005) Copyright © 2016 The Authors Terms and Conditions

Fig. 5 Histological (H&E) response to Zenapro in a rabbit after 6 months. A thick layer of organized, mature collagen has been deposited on the peritoneal side of implant, protecting the internal viscera from the polypropylene core of the device. Inflammation is minimal. Bar = 100 µm. International Journal of Surgery Open 2016 5, 27-32DOI: (10.1016/j.ijso.2016.09.005) Copyright © 2016 The Authors Terms and Conditions

Fig. 6 Histological (H&E) response to Ventralight ST in a rabbit after 6 months. Only a thin layer of collagenous tissue is observed, and the polypropylene core is in direct contact with a thin peritoneal layer void of a protective collagen layer. Bar = 100 µm. International Journal of Surgery Open 2016 5, 27-32DOI: (10.1016/j.ijso.2016.09.005) Copyright © 2016 The Authors Terms and Conditions