Secretory carcinoma of breast: clinicopathologic study of 8 cases

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Secretory carcinoma of breast: clinicopathologic study of 8 cases Nasir Ud Din, MBBS, FCPS, Romana Idrees, MBBS, FCPS, Saira Fatima, MBBS, FCPS, Naila Kayani, MD, FCAP Annals of Diagnostic Pathology Volume 17, Issue 1, Pages 54-57 (February 2013) DOI: 10.1016/j.anndiagpath.2012.06.001 Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 1 Gross appearance of secretory carcinoma (case 5). The tumor is solid grayish white. Annals of Diagnostic Pathology 2013 17, 54-57DOI: (10.1016/j.anndiagpath.2012.06.001) Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 2 (A) A microcystic pattern composed of small cysts and larger spaces containing abundant pink eosinophilic secretions. Also note a lobulated pattern caused by stromal fibrosis (H&E, original magnification ×200). (B) A papillary pattern (on the right) and microcystic pattern (on the left) (H&E, original magnification ×200). Annals of Diagnostic Pathology 2013 17, 54-57DOI: (10.1016/j.anndiagpath.2012.06.001) Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 3 (A) A solid pattern is composed of compact masses of small microlumens containing eosinophilic secretions (inset; original magnification ×400). Note the circumscribed border of tumor (H&E, original magnification ×100). (B) Secretory carcinoma with in situ component (center) (H&E, original magnification ×200). Annals of Diagnostic Pathology 2013 17, 54-57DOI: (10.1016/j.anndiagpath.2012.06.001) Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 4 (A) The secretions were PAS positive after diastase digestion (PAS stain; original magnification ×200). (B) Secretory carcinoma with infiltration into the skeletal muscle (case 7; H&E, original magnification ×200). Annals of Diagnostic Pathology 2013 17, 54-57DOI: (10.1016/j.anndiagpath.2012.06.001) Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 5 Metastatic secretory carcinoma to axillary lymph node (case 5; H&E, original magnification ×200). Annals of Diagnostic Pathology 2013 17, 54-57DOI: (10.1016/j.anndiagpath.2012.06.001) Copyright © 2013 Elsevier Inc. Terms and Conditions