Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia Jacob J. Christensen,

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Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia Jacob J. Christensen, Liv T. Osnes, Bente Halvorsen, Kjetil Retterstøl, Martin P. Bogsrud, Cecilie Wium, Arne Svilaas, Ingunn Narverud, Stine M. Ulven, Pål Aukrust, Kirsten B. Holven Atherosclerosis Volume 256, Pages 67-74 (January 2017) DOI: 10.1016/j.atherosclerosis.2016.11.031 Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Representative flow cytometry plots of the three main monocyte subpopulations. (A) FH child with low HDL-C (<1.3 mmol/L), (B) FH child with high HDL-C (≥1.3 mmol/L), and (C) normocholesterolemic child, illustrating the skewing towards pro-inflammatory cells in the former. Monocytes were gated on SSC/FCS and divided into subpopulations; classical monocytes (CD14++ CD16−), pro-inflammatory monocytes (CD14++ CD16+) and non-classical monocytes (CD14 + CD16+). Atherosclerosis 2017 256, 67-74DOI: (10.1016/j.atherosclerosis.2016.11.031) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Serum concentration of endothelial cell adhesion molecules. (A and B) ICAM-1, (C and D) VCAM-1 and (E and F) E-selectin, as determined by enzyme immunoassays. Lines represent median values within each group. p values are independent samples T test using non-transformed data for ICAM-1 and VCAM-1, and log-transformed data for E-selectin. Atherosclerosis 2017 256, 67-74DOI: (10.1016/j.atherosclerosis.2016.11.031) Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions

Atherosclerosis 2017 256, 67-74DOI: (10. 1016/j. atherosclerosis. 2016 Copyright © 2016 Elsevier Ireland Ltd Terms and Conditions