Invest. Ophthalmol. Vis. Sci ;55(4): doi: /iovs Figure Legend:

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From: Drug and Gene Delivery to the Back of the Eye: From Bench to Bedside Invest. Ophthalmol. Vis. Sci.. 2014;55(4):2714-2730. doi:10.1167/iovs.13-13707 Figure Legend: Innovations for topical drugs that are intended to treat diseases in the back of the eye. Eye drops are one of several drug delivery vehicles that can be modified to deliver medical therapy to the back of the eye. Limitations of some suspensions and solutions include low solubility, poor permeation of the ocular surface and short retention time in the eye. Solutions of polyguanidilyated dendrimers form nano-sized complexes with drugs to enhance their solubility, permeability, and retention. In vitro studies showed that 6-guanyl dendrimeric formulation of gatifloxacin increased the solubility of the antibiotic by 4-fold, increased its transport across a preparation of bovine sclera-choroid-RPE, and enhanced its uptake by human corneal epithelial cells. HDNP may also be used to increase the residence time of drugs on the ocular surface. Animal studies indicated that a hydrogel and dendrimer formulation of two topical antiglaucoma drugs extended the duration of IOP lowering for 4 days in rabbits. Date of download: 11/13/2017 The Association for Research in Vision and Ophthalmology Copyright © 2017. All rights reserved.