Effects of tranexamic acid on postoperative bleeding and related hematochemical variables in coronary surgery: Comparison between on-pump and off-pump.

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Effects of tranexamic acid on postoperative bleeding and related hematochemical variables in coronary surgery: Comparison between on-pump and off-pump techniques Valter Casati, MD, Patrizia Della Valle, BS, Stefano Benussi, MD, PhD, Annalisa Franco, MD, Chiara Gerli, MD, Paolo Baili, MS, Ottavio Alfieri, MD, Armando D'Angelo, MD The Journal of Thoracic and Cardiovascular Surgery Volume 128, Issue 1, Pages 83-91 (July 2004) DOI: 10.1016/j.jtcvs.2003.10.034

Figure 1 Changes (adjusted for hemodilution) in platelet counts (A), D-dimer levels (B), plasminogen levels (C), and α2-antiplasmin levels (D) in patients undergoing OPCAB or ONCAB and receiving placebo or TA at time 1 (after induction of anesthesia), time 2 (10 minutes after arrival in ICU), and time 3 (24 hours after end of operation). Box plots with medians (horizontal lines), interquartile ranges (boxes), and 95% confidence intervals (vertical lines) are shown. Diagonal fills slanting downward from right represent OPCAB and placebo; white fills represent OPCAB and TA; diagonal fills slanting downward from right represent ONCAB and placebo; black fills represent ONCABG and TA. P values refer to analysis of variance for repeated measures (see text for explanation). ns, Not significant. The Journal of Thoracic and Cardiovascular Surgery 2004 128, 83-91DOI: (10.1016/j.jtcvs.2003.10.034)

Figure 2 IL-6 levels (A) at time 2 (after arrival in ICU, unadjusted for hemodilution) and fibrinogen levels (B) and α2-antiplasmin levels (C) at time 3 (24 hours after end of operation) in patients undergoing OPCAB or ONCAB and receiving placebo or TA. Box plots with medians (horizontal lines), interquartile ranges (boxes), and 95% confidence intervals (vertical lines) are shown. Diagonal fills slanting downward from right represent OPCAB and placebo; white fills represent OPCAB and TA; diagonal fills slanting downward from right represent ONCAB and placebo; black fills represent ONCABG and TA. P values refer to analysis of variance for repeated measures (see text for explanation). The Journal of Thoracic and Cardiovascular Surgery 2004 128, 83-91DOI: (10.1016/j.jtcvs.2003.10.034)