From: Using Human CD20-Transfected Murine Lymphomatous B Cells to Evaluate the Efficacy of Intravitreal and Intracerebral Rituximab Injections in Mice.

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Date of download: 6/3/2016 The Association for Research in Vision and Ophthalmology Copyright © All rights reserved. From: Amyloid-β Deposits Lead.

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From: Using Human CD20-Transfected Murine Lymphomatous B Cells to Evaluate the Efficacy of Intravitreal and Intracerebral Rituximab Injections in Mice Invest. Ophthalmol. Vis. Sci.. 2008;49(11):4738-4745. doi:10.1167/iovs.07-1494 Figure Legend: Histopathology of intraocular lymphoma after intravitreal injection of 38C13 CD20+ cells into syngeneic mice. (A) Vitreous colonized by deposits of lymphoma cells in a mouse eye presenting without clinical event, collected 10 days after inoculation. Photomicrograph showing vitreous (V) involvement by small lymphoma cells (arrows) close to the superficial retina (R), which is thickened without obvious tumoral infiltration (hematoxylin and eosin; original magnification, ×400). (B) Retina colonization and invasion by lymphoma cells in an eye harvested 21 days after inoculation. Numerous lymphoma cells in the vitreous cavity (blue arrows) and the retina (blue arrowheads). (Hematoxylin and eosin staining; original magnification, ×400.) (C) Late stage of lymphoma development. The eye was harvested from an animal killed 48 hours after exophthalmia. Lymphoma cells invaded the retinal pigment epithelium and the choroid. A spontaneous hemorrhage (H) occurred in the vitreous (V). Tumoral cells were also localized in the vitreous. The split between retina (R) and subretina is a histologic section artifact that was frequently observed (hematoxylin and eosin; original magnification, ×100). (D) Immunohistochemistry of intraocular tumor. The retinal pigment epithelium is dark and is completely infiltrated by lymphoma cells. Sections were incubated with anti–human CD20 antibody and then stained by diaminobenzidine and Mayer hemalin. Human CD20+ positive cells are strongly stained (brown; original magnification, ×400). Date of download: 11/13/2017 The Association for Research in Vision and Ophthalmology Copyright © 2017. All rights reserved.