Pedigree analysis: determining the pattern of inheritance

Human Pedigrees The use of pedigrees is an important method for analyzing the inheritance of traits in human populations

Patterns of Inheritance Six basic patterns Autosomal dominant Autosomal recessive X-linked dominant X-linked recessive Y-linked Mitochondrial inheritance

New Computer Software can be used to Prepare Pedigrees

Keep In Mind Pedigree construction and analysis are basic methods in human genetics

A Rare Autosomal Recessive Trait

Some Autosomal Recessive Traits

Pedigree: An Autosomal Dominant Trait

Some Autosomal Dominant Traits

Example of an Autosomal Dominant Trait Marfan syndrome Affects the skeletal system, cardiovascular system, and eyes Individuals are tall, thin, long arms and legs–thin fingers Heart defects

Cardiovascular Effects of Marfan Syndrome Aorta Vena cava Pulmonary artery Right auricle Left ventricle Right ventricle

Cardiovascular Effects of Marfan Syndrome Aorta Area of aorta affected in Marfan syndrome Right auricle Left ventricle Right ventricle