Safety, Tolerability and Symptom Outcomes Associated with l-Carnitine Supplementation in Patients with Cancer, Fatigue, and Carnitine Deficiency: A Phase.

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Presentation transcript:

Safety, Tolerability and Symptom Outcomes Associated with l-Carnitine Supplementation in Patients with Cancer, Fatigue, and Carnitine Deficiency: A Phase I/II Study Ricardo A. Cruciani, MD, PhD, Ella Dvorkin, CSW, Peter Homel, PhD, Stephen Malamud, MD, Bruce Culliney, MD, Jeanne Lapin, RN, Russell K. Portenoy, MD, Nora Esteban-Cruciani, MD, MS Journal of Pain and Symptom Management Volume 32, Issue 6, Pages 551-559 (December 2006) DOI: 10.1016/j.jpainsymman.2006.09.001 Copyright © 2006 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 1 Schema. Journal of Pain and Symptom Management 2006 32, 551-559DOI: (10.1016/j.jpainsymman.2006.09.001) Copyright © 2006 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 2 Patient disposition. Journal of Pain and Symptom Management 2006 32, 551-559DOI: (10.1016/j.jpainsymman.2006.09.001) Copyright © 2006 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 3 Analysis of the 17 patients, who after 1-week supplementation, had increased serum carnitine levels (“responders”). Each bar represents a dosing group. There was significant dose response for total carnitine (r=0.54, P=0.03) and for free carnitine (r=0.56, P=0.02). Decrease in fatigue scores (BFI) also showed a significant dose response (r=−0.61, P=0.01). Journal of Pain and Symptom Management 2006 32, 551-559DOI: (10.1016/j.jpainsymman.2006.09.001) Copyright © 2006 U.S. Cancer Pain Relief Committee Terms and Conditions