Case Report of Cirrhosis following Yttrium-90 Radioembolization for Pancreatic Neuroendocrine Liver Metastases Case Rep Oncol 2016;9:76-82 - DOI:10.1159/000443985.

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Case Report of Cirrhosis following Yttrium-90 Radioembolization for Pancreatic Neuroendocrine Liver Metastases Case Rep Oncol 2016;9:76-82 - DOI:10.1159/000443985 Fig. 1. Contrast-enhanced CT imaging demonstrating no cirrhotic changes prior to 90Y administration (a) and generalized mottled changes compatible with postembolization edema 3 months after 90Y administration (b). The patient subsequently developed a large, nonenhancing, complex cystic central hepatic lesion suggestive of a post-90Y biloma 14 months after administration (c) and over the subsequent 45 months developed a progressively irregular texture suggestive of hepatic cirrhosis (d). © 2016 The Author(s). Published by S. Karger AG, Basel - CC BY-NC 4.0

Case Report of Cirrhosis following Yttrium-90 Radioembolization for Pancreatic Neuroendocrine Liver Metastases Case Rep Oncol 2016;9:76-82 - DOI:10.1159/000443985 Fig. 2. Needle core biopsy of the liver taken 47 months after 90Y administration. a There is a large band of chronically inflamed fibrous tissue, highly suggestive of cirrhosis. HE. ×10. b This is highlighted by Masson trichrome staining, demonstrating chronically inflamed fibrous tissue (blue), highly suggestive of cirrhosis. ×10. c The nonfibrotic liver showed macrovesicular steatosis with mildly active steatohepatitis. HE. ×40. d On the other hand, sinusoidal Kupffer cells showed a mild degree of hemosiderosis. Perls iron stain. ×40. © 2016 The Author(s). Published by S. Karger AG, Basel - CC BY-NC 4.0