Figure 1. From categories to molecules

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Presentation transcript:

Figure 1. From categories to molecules Figure 1. From categories to molecules. (a) The Central Dogma of biology defined three categories and a unidirectional information flow (arrows) in which DNA stores the information, and RNA carries the information to proteins that then carry out all biological... Daniel Herschlag, Benjamin E Allred, Seshadri Gowrishankar From static to dynamic: the need for structural ensembles and a predictive model of RNA folding and function Current Opinion in Structural Biology, Volume 30, 2015, 125–133 http://dx.doi.org/10.1016/j.sbi.2015.02.006

Figure 2. Predictions of the behavior of isolated junctions within RNA Figure 2. Predictions of the behavior of isolated junctions within RNA. [Reprinted from [24•]] (a) An idealized single-stranded PEG junction construct (left) and its predicted conformational landscape (right). Green/red sticks (with green distal and red proxim... Daniel Herschlag, Benjamin E Allred, Seshadri Gowrishankar From static to dynamic: the need for structural ensembles and a predictive model of RNA folding and function Current Opinion in Structural Biology, Volume 30, 2015, 125–133 http://dx.doi.org/10.1016/j.sbi.2015.02.006

Figure 3. Conformational ensembles of RNA helix–junction–helix motifs (HJHs). (a) The secondary structure of HIV-1 TAR. Wild-type TAR has a six-nucleotide hairpin loop that for the majority of studies is replaced with the more stable UUCG tetraloop. (b) The Eu... Daniel Herschlag, Benjamin E Allred, Seshadri Gowrishankar From static to dynamic: the need for structural ensembles and a predictive model of RNA folding and function Current Opinion in Structural Biology, Volume 30, 2015, 125–133 http://dx.doi.org/10.1016/j.sbi.2015.02.006

Figure 4. Dynamics and tetraloop–tetraloop receptor (TL/TLR) tertiary motif assembly. (a) The crystal structure of the P4–P6 domain of the Tetrahymena ribozyme with its TL/TLR highlighted in blue (PDB: 1GID [ 48]; left panel) and an overlay of the free (yellow... Daniel Herschlag, Benjamin E Allred, Seshadri Gowrishankar From static to dynamic: the need for structural ensembles and a predictive model of RNA folding and function Current Opinion in Structural Biology, Volume 30, 2015, 125–133 http://dx.doi.org/10.1016/j.sbi.2015.02.006