Inflammatory Cytokines in the BAL of Patients With ARDS

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Presentation transcript:

Inflammatory Cytokines in the BAL of Patients With ARDS G. Umberto Meduri, MD, FCCP, Gary Kohler, MD, Stacey Headley, MD, Elizabeth Tolley, PhD, Frankie Stentz, PhD, Arnold Postlethwaite, MD  CHEST  Volume 108, Issue 5, Pages 1303-1314 (November 1995) DOI: 10.1378/chest.108.5.1303 Copyright © 1995 The American College of Chest Physicians Terms and Conditions

FIGURE 1 Kaplan-Meier survival curve over time. CHEST 1995 108, 1303-1314DOI: (10.1378/chest.108.5.1303) Copyright © 1995 The American College of Chest Physicians Terms and Conditions

FIGURE 2 LIS in survivors (closed triangles) and nonsurvivors (open circles) during the first week of ARDS. CHEST 1995 108, 1303-1314DOI: (10.1378/chest.108.5.1303) Copyright © 1995 The American College of Chest Physicians Terms and Conditions

FIGURE 3 Mean (±SE) BAL albumin and TP levels in survivors and nonsurvivors over time. In nonsurvivors of ARDS (gray bar), mean BAL albumin and TP levels (g/L) remained elevated over time. BAL albumin levels over time were 447±31, 404±54, and 337±61. BAL TP levels over time were 957±53, 788±94, and 695±108. In survivors of ARDS (white bar), mean BAL albumin and TP levels (g/L) rapidly decreased over time. BAL albumin levels over time were 406± 13, 124±27. BAL TP levels over time were 874 ±28 and 281+57. CHEST 1995 108, 1303-1314DOI: (10.1378/chest.108.5.1303) Copyright © 1995 The American College of Chest Physicians Terms and Conditions

FIGURE 4 Relationships among BAL TNF-α, IL-1ß, IL-6, and IL-8 and BAL albumin and TP. CHEST 1995 108, 1303-1314DOI: (10.1378/chest.108.5.1303) Copyright © 1995 The American College of Chest Physicians Terms and Conditions