Human Herpesvirus 6 Reactivation in Drug-induced Hypersensitivity Syndrome and DRESS Validation Score Yukiko Ushigome, MD, Yoko Kano, MD, Kazuhisa Hirahara,

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Presentation transcript:

Human Herpesvirus 6 Reactivation in Drug-induced Hypersensitivity Syndrome and DRESS Validation Score Yukiko Ushigome, MD, Yoko Kano, MD, Kazuhisa Hirahara, MD, Tetsuo Shiohara, MD The American Journal of Medicine Volume 125, Issue 7, Pages e9-e10 (July 2012) DOI: 10.1016/j.amjmed.2011.10.027 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Association between human herpesvirus 6 (HHV-6) DNA loads and cytomegalovirus reactivation in drug-induced hypersensitivity syndrome and drug reaction with eosinophilia and systemic symptoms (DRESS) validation score. HHV-6 DNA and cytomegalovirus DNA in 106 leukocytes were measured by using real-time polymerase chain reaction assay. Final score 4-5=probable case; final score>5=definite case. •=HHV-6 DNA and cytomegalovirus DNA were detected; ○=HHV-6 DNA alone was detected; *=the second time evaluation of cytomegalovirus DNA was not carried out because of sudden death. The American Journal of Medicine 2012 125, e9-e10DOI: (10.1016/j.amjmed.2011.10.027) Copyright © 2012 Elsevier Inc. Terms and Conditions