High-Dose Testosterone Treatment Increases Serotonin Transporter Binding in Transgender People Georg S. Kranz, Wolfgang Wadsak, Ulrike Kaufmann, Markus.

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High-Dose Testosterone Treatment Increases Serotonin Transporter Binding in Transgender People Georg S. Kranz, Wolfgang Wadsak, Ulrike Kaufmann, Markus Savli, Pia Baldinger, Gregor Gryglewski, Daniela Haeusler, Marie Spies, Markus Mitterhauser, Siegfried Kasper, Rupert Lanzenberger Biological Psychiatry Volume 78, Issue 8, Pages 525-533 (October 2015) DOI: 10.1016/j.biopsych.2014.09.010 Copyright © 2015 Society of Biological Psychiatry Terms and Conditions

Figure 1 Line chart showing changes in serotonin transporter (SERT) binding potential (BPND) and plasma levels of testosterone and estradiol in female-to-male and male-to-female transsexuals over the course of cross-sex steroid treatment. Depicted are means ± 95% confidence interval at positron emission tomography (PET) 1, i.e., baseline (BL), after 4 weeks (4w) of treatment at PET 2, and after 4 months (4m) of treatment at PET 3. Biological Psychiatry 2015 78, 525-533DOI: (10.1016/j.biopsych.2014.09.010) Copyright © 2015 Society of Biological Psychiatry Terms and Conditions

Figure 2 Scatter plots depicting associations between the change in serotonin reuptake transporter (SERT) binding potential (BP) and in plasma steroid hormones for (A) female-to-male (FtM) and (B) male-to-female (MtF) transsexuals. Scattered lines represent 95% confidence intervals. Positive associations between changes in SERT BP in amygdala, caudate, and putamen and testosterone plasma level increase within the first 4 weeks (4w) of treatment (baseline [BL] − 4w) were found in FtM transsexuals (upper row). Positive associations between changes in SERT BP in insula, mid-cingulate, and putamen and estradiol plasma level increase over the course of 4 months (4m) of treatment (BL − 4m) were found in FtM transsexuals (bottom row). PET, positron emission tomography. Biological Psychiatry 2015 78, 525-533DOI: (10.1016/j.biopsych.2014.09.010) Copyright © 2015 Society of Biological Psychiatry Terms and Conditions