Basic elements of renal-body fluid feedback mechanism for long-term regulation of blood pressure. A key component of this feedback is the effect of arterial pressure on urine sodium excretion, called pressure natriuresis/diuresis. The red dashed lines show altered pressure natriuresis in salt-sensitive and salt-resistant hypertension. Increased arterial pressure may cause secondary increases in total peripheral resistance via pressure-dependent or flow-dependent “autoregulation” in various tissues. Increased vascular capacity tends to reduce mean circulatory filling pressure. Source: PATHOPHYSIOLOGY OF HYPERTENSION, Hurst's The Heart, 14e Citation: Fuster V, Harrington RA, Narula J, Eapen ZJ. Hurst's The Heart, 14e; 2017 Available at: http://accessmedicine.mhmedical.com/DownloadImage.aspx?image=/data/books/2046/hurst14_ch24_f004.png&sec=170883203&BookID=2046&ChapterSecID=155631863&imagename= Accessed: November 14, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved