Brain Trauma Induces Massive Hippocampal Neuron Death Linked to a Surge in β- Amyloid Levels in Mice Overexpressing Mutant Amyloid Precursor Protein Douglas.

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Brain Trauma Induces Massive Hippocampal Neuron Death Linked to a Surge in β- Amyloid Levels in Mice Overexpressing Mutant Amyloid Precursor Protein Douglas H. Smith, Michio Nakamura, Tracy K. McIntosh, Jun Wang, Amarís Rodríguez, Xiao-Han Chen, Ramesh Raghupathi, Kathryn E. Saatman, James Clemens, M. Luise Schmidt, Virginia M-Y Lee, John Q. Trojanowski The American Journal of Pathology Volume 153, Issue 3, Pages 1005-1010 (September 1998) DOI: 10.1016/S0002-9440(10)65643-X Copyright © 1998 American Society for Investigative Pathology Terms and Conditions

Figure 1 Histogram demonstrating relative memory retention of a water maze task of wild-type and PDAPP mice one week following brain trauma or sham treatment. *P < 0.01, **P < 0.001. The American Journal of Pathology 1998 153, 1005-1010DOI: (10.1016/S0002-9440(10)65643-X) Copyright © 1998 American Society for Investigative Pathology Terms and Conditions

Figure 2 Representative Nissl-stained coronal brain sections of the dorsal hippocampi of PDAPP and wild-type mice one week following sham treatment or brain trauma. A: Normal neuron density and orientation of the hippocampus in a PDAPP mouse. B: Typical loss of neurons in the CA2 and CA3 subfield of brain injured wild-type mice (small arrows), C-F: Hippocampi from four brain-injured PDAPP mice demonstrating an almost complete loss of CA3 neurons (large arrow, c). The American Journal of Pathology 1998 153, 1005-1010DOI: (10.1016/S0002-9440(10)65643-X) Copyright © 1998 American Society for Investigative Pathology Terms and Conditions

Figure 3 Histogram demonstrating neuron cell loss in the CA2 and CA3 region of the hippocampus of brain injured wild-type and PDAPP mice. *P < 0.001 compared to respective sham group.†P < 0.001 compared to brain injured wild-type mice. The American Journal of Pathology 1998 153, 1005-1010DOI: (10.1016/S0002-9440(10)65643-X) Copyright © 1998 American Society for Investigative Pathology Terms and Conditions

Figure 4 Histogram demonstrating the temporal changes in the concentration of Aβ 1–40 and Aβ1–42 following brain trauma in PDAPP mice in the hippocampus and cortex. *P < 0.01, **P < 0.001 compared to respective sham Aβ levels. Data are not shown for wild-type mice because their Aβ levels were at the minimal detection limit (6 fmol/well) or below for all time points. The American Journal of Pathology 1998 153, 1005-1010DOI: (10.1016/S0002-9440(10)65643-X) Copyright © 1998 American Society for Investigative Pathology Terms and Conditions