The 3-compartment pharmacokinetic model

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Copyright © 2015 Wolters Kluwer All Rights Reserved Chapter 1: Pharmacokinetics.
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The 3-compartment pharmacokinetic model The 3-compartment pharmacokinetic model. The terms in the exponential equation (Figure 1–6) are rearranged as compartment volumes and rate constants between compartments. A 3-compartment model is used to describe an exponential equation with 3 terms. Rate constants are converted into clearance rates. Compartment volumes and clearances are used to generate predictions of drug concentration for various dosing regimens. IV, intravenous. Source: Pharmacokinetics, Biophase, and Pharmacodynamics and the Importance of Simulation, Clinical Pharmacology for Anesthesiology Citation: Johnson KB. Clinical Pharmacology for Anesthesiology; 2015 Available at: https://accessanesthesiology.mhmedical.com/DownloadImage.aspx?image=/data/books/1181/joh_ch1_f007.png&sec=65651647&BookID=1181&ChapterSecID=65651568&imagename= Accessed: November 14, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

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