(A) Region of esophagus demonstrating Barrett esophagus: The normal squamous epithelium (left margin of figure) is replaced by specialized columnar epithelium.

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(A) Region of esophagus demonstrating Barrett esophagus: The normal squamous epithelium (left margin of figure) is replaced by specialized columnar epithelium with scattered goblet cells similar to that seen in the intestine (arrow). Other areas show cardiac type mucosa similar to that observed in the gastric cardia (white arrow). Areas of the biopsy show evidence of dysplasia with hyperchromatic-stacked nuclei both in surface mucosa and within glands (line). (B) Region of esophagus demonstrating adenocarcinoma: The biopsy specimen discloses poorly differentiated adenocarcinoma (short arrow) invading through the submucosa (line) adjacent to an area showing metaplasia (arrow). Source: Cell Injury, Cell Death, and Aging, Pathology: A Modern Case Study Citation: Reisner HM. Pathology: A Modern Case Study; 2015 Available at: https://accessmedicine.mhmedical.com/DownloadImage.aspx?image=/data/books/1569/rei_ch2_f015.png&sec=95968246&BookID=1569&ChapterSecID=95968199&imagename= Accessed: November 14, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

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