Abundant ghrelin gene expression by monocytes: Putative implications for fat accumulation and obesity Inge Seim, Gabrielle Crisp, Esha T. Shah, Penny.

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Abundant ghrelin gene expression by monocytes: Putative implications for fat accumulation and obesity Inge Seim, Gabrielle Crisp, Esha T. Shah, Penny L. Jeffery, Lisa K. Chopin Obesity Medicine Volume 5, Pages 1-3 (March 2017) DOI: 10.1016/j.obmed.2016.12.001 Copyright © 2017 The Authors Terms and Conditions

Fig. 1 A. A box plot reveals high GHRL expression in monocytes and associated tissues (red dots). From the Human Protein Atlas: adipose tissue, adrenal gland, appendix, bone marrow, cerebral cortex, colon, duodenum, endometrium, oesophagus, gall bladder, kidney, liver, lung, lymph node, ovary, pancreas, placenta, prostate, rectum, salivary gland, skeletal muscle, skin, small intestine, smooth muscle, spleen, stomach, testis, thyroid gland, tonsil, urinary bladder, and uterine tube. From ENCODE: keratinocytes, (CD4+) monocytes, and osteoblasts. B. Integrative Genomics Viewer (IGV) visualisation of the GHRL locus in monocytes validates expression of all canonical preproghrelin-coding exons. C. Monocyte GHRL expression is reduced 3 months after bariatric surgery. Mean ± S.E.M. P value, Student's t-test. D. GHRL expression (qRT-PCR) in human THP-1 leukaemia leukemia cells treated with 50 ng/ml interferon-γ (IFN-γ) for 24 h (n = 6 per group), compared to untreated controls. Mean ± S.E.M. **P ≤ 0.01, Mann–Whitney U test. Obesity Medicine 2017 5, 1-3DOI: (10.1016/j.obmed.2016.12.001) Copyright © 2017 The Authors Terms and Conditions