Misako Nakashima, PhD, DDS, Akifumi Akamine, PhD, DDS

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Presentation transcript:

The Application of Tissue Engineering to Regeneration of Pulp and Dentin in Endodontics Misako Nakashima, PhD, DDS, Akifumi Akamine, PhD, DDS Journal of Endodontics Volume 31, Issue 10, Pages 711-718 (October 2005) DOI: 10.1097/01.don.0000164138.49923.e5 Copyright © 2005 The American Association of Endodontists Terms and Conditions

Figure 1 Regenerative dentin formation by two main strategies. (A) In vivo method. Induction of osteodentin formation by ultrasound-mediated Growth/differentiation factor (Gdf11) gene transfer on the amputated pulp in canine teeth after one month. (B) Ex vivo method. Pulp stem/progenitor cells are first isolated, transduced with Gdf11 gene by electroporation to differentiate into odontoblasts and autogenously transplanted on the amputated pulp. A large amount of osteodentin and tubular dentin formation after 3 months. Journal of Endodontics 2005 31, 711-718DOI: (10.1097/01.don.0000164138.49923.e5) Copyright © 2005 The American Association of Endodontists Terms and Conditions

Figure 2 Dentin-pulp complex formation with optimal orientation for clinical application of regenerative therapy. The pulp stem cells are transduced with BMP gene and attached to a defined scaffold to differentiate into odontoblasts. The tubular dentin-pulp complex can be transplanted on the exposed or amputated pulp in the cavity. Journal of Endodontics 2005 31, 711-718DOI: (10.1097/01.don.0000164138.49923.e5) Copyright © 2005 The American Association of Endodontists Terms and Conditions

Journal of Endodontics 2005 31, 711-718DOI: (10. 1097/01. don Journal of Endodontics 2005 31, 711-718DOI: (10.1097/01.don.0000164138.49923.e5) Copyright © 2005 The American Association of Endodontists Terms and Conditions

Journal of Endodontics 2005 31, 711-718DOI: (10. 1097/01. don Journal of Endodontics 2005 31, 711-718DOI: (10.1097/01.don.0000164138.49923.e5) Copyright © 2005 The American Association of Endodontists Terms and Conditions

Journal of Endodontics 2005 31, 711-718DOI: (10. 1097/01. don Journal of Endodontics 2005 31, 711-718DOI: (10.1097/01.don.0000164138.49923.e5) Copyright © 2005 The American Association of Endodontists Terms and Conditions