P. Therasse, S. Carbonnelle, J. Bogaerts

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Presentation transcript:

Clinical trials design and treatment tailoring: General principles applied to breast cancer research P. Therasse, S. Carbonnelle, J. Bogaerts Critical Reviews in Oncology / Hematology Volume 59, Issue 2, Pages 98-105 (August 2006) DOI: 10.1016/j.critrevonc.2005.11.003 Copyright © 2006 Terms and Conditions

Fig. 1 Trial design SOFT. Critical Reviews in Oncology / Hematology 2006 59, 98-105DOI: (10.1016/j.critrevonc.2005.11.003) Copyright © 2006 Terms and Conditions

Fig. 2 Trial design TEXT. Critical Reviews in Oncology / Hematology 2006 59, 98-105DOI: (10.1016/j.critrevonc.2005.11.003) Copyright © 2006 Terms and Conditions

Fig. 3 Trial design PERCHE. Critical Reviews in Oncology / Hematology 2006 59, 98-105DOI: (10.1016/j.critrevonc.2005.11.003) Copyright © 2006 Terms and Conditions

Fig. 4 Trial design to test the overall predictive value of a marker. Critical Reviews in Oncology / Hematology 2006 59, 98-105DOI: (10.1016/j.critrevonc.2005.11.003) Copyright © 2006 Terms and Conditions

Fig. 5 Trial design to test if treatment A or B best suits for marker positive/negative patients. Critical Reviews in Oncology / Hematology 2006 59, 98-105DOI: (10.1016/j.critrevonc.2005.11.003) Copyright © 2006 Terms and Conditions

Fig. 6 Trial design allowing the evaluation of both the treatment and the marker effect. Critical Reviews in Oncology / Hematology 2006 59, 98-105DOI: (10.1016/j.critrevonc.2005.11.003) Copyright © 2006 Terms and Conditions

Fig. 7 Registration design. Critical Reviews in Oncology / Hematology 2006 59, 98-105DOI: (10.1016/j.critrevonc.2005.11.003) Copyright © 2006 Terms and Conditions

Fig. 8 Two-way stratified design. Critical Reviews in Oncology / Hematology 2006 59, 98-105DOI: (10.1016/j.critrevonc.2005.11.003) Copyright © 2006 Terms and Conditions

Fig. 9 Classifier randomization design. Critical Reviews in Oncology / Hematology 2006 59, 98-105DOI: (10.1016/j.critrevonc.2005.11.003) Copyright © 2006 Terms and Conditions

Fig. 10 Proposed classification matrix for novel molecularly targeted therapies. Critical Reviews in Oncology / Hematology 2006 59, 98-105DOI: (10.1016/j.critrevonc.2005.11.003) Copyright © 2006 Terms and Conditions