Pregnancy persistently affects memory T cell populations

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Pregnancy persistently affects memory T cell populations Tom E.C. Kieffer, Marijke M. Faas, Sicco A. Scherjon, Jelmer R. Prins Journal of Reproductive Immunology Volume 119, Pages 1-8 (February 2017) DOI: 10.1016/j.jri.2016.11.004 Copyright © 2016 The Authors Terms and Conditions

Fig. 1 A representative example of a FACS data analysis. First, a gate was set around lymphocytes in the forward/sideward (FSC/SSC) scatterplot of all events (A). Lymphocytes were copied in a histogram in which CD3+ cells (T-lymphocytes) were identified (B). In a density dot plot of the CD3+ T-lymphocytes, CD4+ and CD8+ cells were distinguished (C). Then, within the CD4+ cell population (CD8+ cell population not shown), CD45RO+ cells were gated in a histogram (D); within the CD4+CD45RO+ cell population, CCR7+ (central memory) cells, CCR7- (effector memory) cells (E) and activated (CD69+) cells (F) were distinguished. Journal of Reproductive Immunology 2017 119, 1-8DOI: (10.1016/j.jri.2016.11.004) Copyright © 2016 The Authors Terms and Conditions

Fig. 2 T-lymphocytes distribution in nulligravid, primigravid and parous women. Proportions and absolute cell counts of T-lymphocytes (CD3+) (A and D), CD4+ cells (B and E), and CD8+ cells (C and F). Frequencies as proportions of white blood cells (WBC) (A) or T-lymphocytes (B and C). Symbols represent individual values per donor and horizontal lines indicate means ± SEM. Analysis by one-way ANOVA followed by Tukey’s post hoc test; *p<0.05, ***p<0.001, ****p<0.0001. Journal of Reproductive Immunology 2017 119, 1-8DOI: (10.1016/j.jri.2016.11.004) Copyright © 2016 The Authors Terms and Conditions

Fig. 3 CD4+ memory cells in nulligravid, primigravid and parous women. Proportions and absolute cell counts of CD4+ memory (CD4+CD45RO+) cells (A and D), central memory (CM; CD4+CD45RO+CCR7+) cells (B and E) and effector memory (EM; CD4+CD45RO+CCR7-) cells (C and F). Frequencies as proportions of CD4+ cells. Symbols represent individual values per donor and horizontal lines indicate means ± SEM. Analysis by one-way ANOVA followed by Tukey’s post hoc test; *p<0.05, **p<0.01, ***p<0.001. Journal of Reproductive Immunology 2017 119, 1-8DOI: (10.1016/j.jri.2016.11.004) Copyright © 2016 The Authors Terms and Conditions

Fig. 4 CD8+ memory cells in nulligravid, primigravid and parous women. Proportions and absolute cell counts of CD8+ memory (CD8+CD45RO+) cells (A and D), CD8+ central memory (CM; CD45RO+CCR7+) cells (B and E) and CD8+ effector memory (EM; CD45RO+CCR7-) cells (C and F). Frequencies as proportions of CD8+ cells. Symbols represent individual values per donor and horizontal lines indicate means ± SEM. Analysis by one-way ANOVA followed by Tukey’s post hoc test; *p<0.05. Journal of Reproductive Immunology 2017 119, 1-8DOI: (10.1016/j.jri.2016.11.004) Copyright © 2016 The Authors Terms and Conditions

Fig. 5 Activated T-lymphocytes in nulligravid, primigravid and parous women. Proportions of activated (CD69+) cells of CD4+ cells (A), CD4+ memory cells (B), CD4+ central memory (CM; CD45RO+CCR7+) cells (C), CD4+ effector memory (EM; CD45RO+CCR7-) cells (D), CD8+ cells (E), CD8+ memory cells (F), CD8+ central memory (CM; CD45RO+CCR7+) cells (G), and CD8+ effector memory (EM; CD45RO+CCR7-) cells (H). Symbols represent individual values per donor and horizontal lines indicate means ± SEM. Analysis by one-way ANOVA followed by Tukey’s post hoc test; *p<0.05, ***p<0.001, ****p<0.0001. Journal of Reproductive Immunology 2017 119, 1-8DOI: (10.1016/j.jri.2016.11.004) Copyright © 2016 The Authors Terms and Conditions