Erythropoiesis Sunita Mittal.

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Hematopoiesis (The formation of Blood Cells)‏

Presentation transcript:

Erythropoiesis Sunita Mittal

Learning Objectives Stem cells Process of erythropoiesis - site, stages Factors affecting erythropoiesis

Hematopoiesis The process of formation of new blood cells

Lineage Cells of Hematopoiesis- HSCs Hemopoietic Stem Cells ▫ Blood (Hemopoietic) Stem Cells are divided into: 1. Myeloid stem cells or 2. Lymphoid stem cells In bone marrow

Stem Cells Stem cells : Cells that are able to 1) Self-renew to form ‘parent pool’ (can create more stem cells indefinitely) 2) Differentiate into (become) specialized, mature cell types.

Site of Hematopoiesis After birth During fetal life Active (red) BM: In infancy & childhood In adult 1) Yolk sac: 2) Liver & Spleen: 3) Bone marrow (BM):

Characteristics of Bone Marrow One of the largest organs in body. 1011-1012 Cells are daily formed to be taken to the periphery through blood vessels

Steps of Erythropoiesis HSC Lymphoid Stem Cells Myeloid Stem Cells Colony Forming Unit-Blast (CFU-B)→ Colony Forming Unit-Erythroblast (CFU-E) Colony Forming Unit – Spleen (CFU-S) → CFU GM → CFU M COMMITTED STEM CELLS or Progenitor cells ▪ MSC ▪ CFU-B ▪ CFU-E Pronormoblast Basophilic normoblast Polychromatophilic Normoblast Orthrochromatophilic Normoblast Reticulocyte Mature Red Blood Cell

Stages of Erythropoiesis Pronormoblast (Proerythroblast)

Stages of Erythropoiesis Early Normoblast (basophilic normoblast)

Stages of Erythropoiesis Intermediate normoblast (polychromatic normoblast)

Stages of Erythropoiesis Late Normoblast (Orthochromatic Normoblast)

Stages of Erythropoiesis Reticulocyte Mature RBC

Factors regulating Erythropoiesis Φ Growth or Developmental Factors Φ Nutritional Factors Φ Hormonal Factors Φ Healthy Liver and Bone marrow

Self Assessment 1) After birth all blood cells except ………………………. are formed in bone marrow. 2) In adults hemopoietic bone marrow is confined to axial skeleton and ………………….of humerus & femur. 3) Interleukins …………………………………..to convert PHSC to Committed Progenitor cells. 4) ……………………………can be stimulated to form any cell in the body. 5) Hemoglobin first appears in ……………………………….stage of Erythropoiesis. 6) In early normoblast stage of Erythropoiesis, cell cytoplasm is stained by ………………… dye. 7) Erythropoietin is secreted from ……………………….of kidney. 8) ………………………….are important in the maturation of the RBCs. 9) RBCs do not contain a nucleus, endoplasmic reticulum and ……………………. 10) 1 gm of hemoglobin contains………………………….iron.

Thank you