Alzheimer's disease biomarker-based clusters predict amyloid accumulation and cognitive decline in a preclinical cohort: Findings from the wisconsin registry.

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Alzheimer's disease biomarker-based clusters predict amyloid accumulation and cognitive decline in a preclinical cohort: Findings from the wisconsin registry for Alzheimer’s prevention (WRAP) Annie M. Racine, Christopher R. Nicholas, Lindsay R. Clark, Rebecca L. Koscik, Ozioma C. Okonkwo, Ansel T. Hillmer, Dhanabalan Murali, Todd E. Barnhart, Catherine L. Gallagher, Howard A. Rowley, N. Maritza Dowling, Sanjay Asthana, Barbara B. Bendlin, Kaj Blennow, Henrik Zetterberg, Cynthia M. Carlsson, Bradley T. Christian, Sterling C. Johnson Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 11, Issue 7, Pages P47-P49 (July 2015) DOI: 10.1016/j.jalz.2015.06.084 Copyright © 2015 Terms and Conditions

Figure 1 Four emergent clusters from hierarchical clustering. n=34 in cluster 1; n=35 in cluster 2; n=23 in cluster 3; n=11 in cluster 4. ANOVA showed the following significant differences between clusters by biomarker at p<0.05: CSF Aβ42(4>1>2<4; CSF t-tau 3>4>2>1; PiB DVR 4>(3,2,1). Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2015 11, P47-P49DOI: (10.1016/j.jalz.2015.06.084) Copyright © 2015 Terms and Conditions

Figure 2 Lateral and medial views of statistical maps thresholded at p<0.001 from PiB ANCOVA rendered onto a template brain. Regions where cluster 4 had greater amyloid accumulation than A) cluster 3, B) cluster 2, and C) cluster 1. Colorbars of T-values ranging from 0-6 are on the right. Significant peaks and clusters (p<0.05 with family wise error correction for multiple comparisons) are described in Table 1. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2015 11, P47-P49DOI: (10.1016/j.jalz.2015.06.084) Copyright © 2015 Terms and Conditions

Figure 3 WM S-R estimated marginal means of Logical Memory A) Immediate Recall and B) Delayed Recall. Cluster 4 scored worse than cluster 1 on Immediate Recall and worse than clusters 1, 2, and 3 on Delayed Recall at p<0.05. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2015 11, P47-P49DOI: (10.1016/j.jalz.2015.06.084) Copyright © 2015 Terms and Conditions