Neuron Model To model a neuron at the ionic level Modelling Goal

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Presentation transcript:

Neuron Model To model a neuron at the ionic level Modelling Goal Brendan Frick | Professor Uri Wilensky| EECS 372 Modelling Goal Channel Selectivity Channel States Results To model a neuron at the ionic level 1. 2. Neuron Properties Neuron Properties Voltage Gating Membrane Potential Modelled current clamp Action Potential Action Potential 4. K+, Na+, Ca++, and Cl- ions Impassable cell membrane Selective, voltage gated transmembrane channel proteins Electrophysiological response 3. NetLogo Properties Turtles - Ions Turtles own Classifier (type of ion) Charge (-1, 0, +1, +2) Ionic Radius Location – intra/extracellular Turtles do Interact with ions Interact with channels Move randomly Patches – Cell Membrane Patches own Opening criteria Selectivity to classifiers Impassability Patches do Attract ions Push ions through membrane Switch location variable of turtles Neuron Model Equilibrium Cell Modelled current clamp tail current Conclusion It is possible to model a functional neuron using ABM. Equilibrium concentration is feasible; equilibrium kinetics are harder to achieve Equilibrium effects can be achieved by micromanaging ion concentrations and channel densities Next steps will be retooling channel state dynamics with Markov chains, introducing more voltage gated and ligand gated channels, and adding in repolarization features Modelled current clamp response Model Parameters Ion Concentrations To model different cell environments Slider values for each type of ion Affects concentration gradient Membrane Channel Density To model different cell characteristics Slider probabilities for each channel type Affects membrane conductance Inactivation Determination To model methods for channel inactivation Internal parameter because of complexity Affects ion flow kinetics Works Cited Marbán, E. Cardiac channelopathies. Nature 415, 213-218 (2002). “Neuronal Action Potential.” PhysiologyWeb. N.p., n.d. Web. 07 June 2015. Eva Horne et al., Principles of Biology. OpenStaxCNX. 07 Junes, 2015. http://cnx.org/contents/db89c8f8-a27c-468-ad2a-19d11a2a7e2e@21.1. “Addiction.” NIH Office of Science Education N.p., n.d. Web 07 June 2015.