Copyright © 2006 American Medical Association. All rights reserved. From: Occult With No Classic Subfoveal Choroidal Neovascular Lesions in Age-Related Macular DegenerationClinically Relevant Natural History Information in Larger Lesions With Good Vision From the Verteporfin in Photodynamic Therapy (VIP) Trial: VIP Report No. 4 Arch Ophthalmol. 2006;124(5):660-664. doi:10.1001/archopht.124.5.660 Figure Legend: Flow diagram for 89 occult with no classic lesions assigned to the placebo group in the Verteporfin in Photodynamic Therapy Trial stratified by baseline visual acuity, with subsequent outcomes by conversion to predominantly classic lesions (area of classic CNV ≥50% of the entire lesion area). For lesions that did not convert to a predominantly classic lesion, subsequent outcomes judged to be clinically relevant for lesions that developed lower levels of visual acuity (approximate Snellen equivalent, ≤20/50−1) are shown. CNV indicates choroidal neovascularization; Minimally classic CNV, an area of classic CNV >0% but <50% of the entire lesion; MPS indicates Macular Photocoagulation Study; and DA, disc areas. Date of download: 11/15/2017 Copyright © 2006 American Medical Association. All rights reserved.

Copyright © 2006 American Medical Association. All rights reserved. From: Occult With No Classic Subfoveal Choroidal Neovascular Lesions in Age-Related Macular DegenerationClinically Relevant Natural History Information in Larger Lesions With Good Vision From the Verteporfin in Photodynamic Therapy (VIP) Trial: VIP Report No. 4 Arch Ophthalmol. 2006;124(5):660-664. doi:10.1001/archopht.124.5.660 Figure Legend: Number of eyes with occult with no classic lesions at baseline that converted to minimally classic (area of classic CNV >0% but <50% of the entire lesion) or predominantly classic (area of classic CNV ≥50% of the entire lesion area) lesions by the 12-month or 24-month follow-up examination. Date of download: 11/15/2017 Copyright © 2006 American Medical Association. All rights reserved.

Copyright © 2006 American Medical Association. All rights reserved. From: Occult With No Classic Subfoveal Choroidal Neovascular Lesions in Age-Related Macular DegenerationClinically Relevant Natural History Information in Larger Lesions With Good Vision From the Verteporfin in Photodynamic Therapy (VIP) Trial: VIP Report No. 4 Arch Ophthalmol. 2006;124(5):660-664. doi:10.1001/archopht.124.5.660 Figure Legend: Late-phase fluorescein angiogram of a study participant judged to have an occult with no classic lesion (>4 disc areas) at baseline (A) with a visual acuity (approximate Snellen equivalent) of 20/50 or higher. Database information at the 6-month examination indicates evidence of classic choroidal neovascularization (CNV). Subsequent grading of lesion composition of the fluorescein angiogram at the 6-month examination (B) indicates a minimally classic lesion (very bright area of fluorescence in the superotemporal portion of the lesion within a larger area of occult CNV) in which the area of classic CNV is less than 50% of the entire lesion (>4 disc areas), with a visual acuity of 20/63−2. Date of download: 11/15/2017 Copyright © 2006 American Medical Association. All rights reserved.

Copyright © 2006 American Medical Association. All rights reserved. From: Occult With No Classic Subfoveal Choroidal Neovascular Lesions in Age-Related Macular DegenerationClinically Relevant Natural History Information in Larger Lesions With Good Vision From the Verteporfin in Photodynamic Therapy (VIP) Trial: VIP Report No. 4 Arch Ophthalmol. 2006;124(5):660-664. doi:10.1001/archopht.124.5.660 Figure Legend: Late-phase fluorescein angiogram of a study participant judged to have an occult with no classic lesion (≤ 4 disc areas) at baseline (A) with a visual acuity (approximate Snellen equivalent) of 20/50+2. The bright area of fluorescence in the center of the lesion was judged to be due to atrophy of the retinal pigment epithelium overlying the occult choroidal neovascularization (CNV) and not classic CNV when the entire fluorescein angiogram was reviewed stereoscopically. Database information at the 12-month examination indicates evidence of classic CNV. Subsequent grading of lesion composition at the 12-month examination (B) indicates conversion to a predominantly classic lesion (≤ 9 disc areas) in which the area of classic CNV is at least 50% of the entire lesion, surrounded by a smaller area of occult CNV, with a visual acuity of 20/200−2. Date of download: 11/15/2017 Copyright © 2006 American Medical Association. All rights reserved.