From: Design of a Cooling Guide Catheter for Rapid Heart Cooling Date of download: 11/15/2017 Copyright © ASME. All rights reserved. From: Design of a Cooling Guide Catheter for Rapid Heart Cooling J. Med. Devices. 2010;4(3):035001-035001-8. doi:10.1115/1.4002063 Figure Legend: CoolGuide™ catheter without outer braiding: (1) inlet coolant lumen, (2) outlet coolant lumen, (3) blood and angioplasty use lumen, and (4) coolant turn around slot at distal tip

From: Design of a Cooling Guide Catheter for Rapid Heart Cooling Date of download: 11/15/2017 Copyright © ASME. All rights reserved. From: Design of a Cooling Guide Catheter for Rapid Heart Cooling J. Med. Devices. 2010;4(3):035001-035001-8. doi:10.1115/1.4002063 Figure Legend: CoolGuide™ heat transfer processes, three processes (Q1,Q4, and Q5) exchange heat from the aorta blood to either coolant or internal blood flow and two process (Q2 and Q3) exchange heat from the internal blood flow to coolant flow. The net cooling effect results from Q2 and Q3 exceeding Q5.

From: Design of a Cooling Guide Catheter for Rapid Heart Cooling Date of download: 11/15/2017 Copyright © ASME. All rights reserved. From: Design of a Cooling Guide Catheter for Rapid Heart Cooling J. Med. Devices. 2010;4(3):035001-035001-8. doi:10.1115/1.4002063 Figure Legend: CoolGuide™ thermal resistance network. Heat flows from left to right in the network. This network represents how heat flows radially at every point along the length of the catheter. Heat transfer between coolant pathways was neglected.

From: Design of a Cooling Guide Catheter for Rapid Heart Cooling Date of download: 11/15/2017 Copyright © ASME. All rights reserved. From: Design of a Cooling Guide Catheter for Rapid Heart Cooling J. Med. Devices. 2010;4(3):035001-035001-8. doi:10.1115/1.4002063 Figure Legend: Predicted performance results for the eccentric and concentric catheter designs. Model predicts that the concentric and eccentric devices will meet the required minimum cooling capacity of 20 W at 10 ml/min and 18 ml/min, respectively.

From: Design of a Cooling Guide Catheter for Rapid Heart Cooling Date of download: 11/15/2017 Copyright © ASME. All rights reserved. From: Design of a Cooling Guide Catheter for Rapid Heart Cooling J. Med. Devices. 2010;4(3):035001-035001-8. doi:10.1115/1.4002063 Figure Legend: Schematic of the in vitro test setup, showing CoolGuide™ catheter placement in a glass aorta. Flow is pumped in two circuits: one circuit carries systemic flow through the glass aorta and one circuit carries internal flow through the catheter. The dashed lines near the catheter represent coolant connection lines; these lines are connected to the cooling console.

From: Design of a Cooling Guide Catheter for Rapid Heart Cooling Date of download: 11/15/2017 Copyright © ASME. All rights reserved. From: Design of a Cooling Guide Catheter for Rapid Heart Cooling J. Med. Devices. 2010;4(3):035001-035001-8. doi:10.1115/1.4002063 Figure Legend: CoolGuide™ eccentric coolant pressure-flow behavior. The average coolant temperature was approximately 10°C. Large differences were attributed to the nonlinear dependence on hydraulic diameter, PTFE wall deformation during the circulation process, and extrusion process limitations.

From: Design of a Cooling Guide Catheter for Rapid Heart Cooling Date of download: 11/15/2017 Copyright © ASME. All rights reserved. From: Design of a Cooling Guide Catheter for Rapid Heart Cooling J. Med. Devices. 2010;4(3):035001-035001-8. doi:10.1115/1.4002063 Figure Legend: CoolGuide™ cooling capacity compared to model prediction. Error bars indicate sample standard deviations for three different catheter prototypes. These prototypes demonstrated the ability to achieve cooling capacity requirements (20 W) at flow rates above 20 ml/min.

From: Design of a Cooling Guide Catheter for Rapid Heart Cooling Date of download: 11/15/2017 Copyright © ASME. All rights reserved. From: Design of a Cooling Guide Catheter for Rapid Heart Cooling J. Med. Devices. 2010;4(3):035001-035001-8. doi:10.1115/1.4002063 Figure Legend: Device and temperature probe locations. Temperature probes were placed in three locations labeled 1–3. CoolGuide™ is shown inserted into the LAD.

From: Design of a Cooling Guide Catheter for Rapid Heart Cooling Date of download: 11/15/2017 Copyright © ASME. All rights reserved. From: Design of a Cooling Guide Catheter for Rapid Heart Cooling J. Med. Devices. 2010;4(3):035001-035001-8. doi:10.1115/1.4002063 Figure Legend: Typical myocardium temperatures. The temperature readings of three probes during LAD cooling using CoolGuide™ without artery occlusion are shown. A temperature drop of 3°C occurred in about 5 min (probe 3). Cooling is localized, i.e., probe 1 location experiences minimal decrease in temperature.