Volume 71, Issue 1, Pages (January 2007)

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Volume 71, Issue 1, Pages 74-78 (January 2007) Plasma creatinine determination in mice and rats: An enzymatic method compares favorably with a high-performance liquid chromatography assay A. Keppler, N. Gretz, R. Schmidt, H-M. Kloetzer, H-J. Groene, B. Lelongt, M. Meyer, M. Sadick, J. Pill Kidney International Volume 71, Issue 1, Pages 74-78 (January 2007) DOI: 10.1038/sj.ki.5001988 Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 1 Method comparison of creatinine measurement in mouse and rat plasma. Comparison of HPLC, enzymatic, and colorimetric method in (a–d) mice and (e–h) rats. (a, c, e, and g) scatter plots with regression line (solid), line of identity (broken), regression equation, and coefficient of determination (r2) as well as (b, d, f, h) Bland–Altman plots for the comparison of creatinine concentrations in spiked (0.4mg/dl creatinine added) and unspiked plasma of healthy as well as diseased mice (n=61, plus 61 spiked samples) and rats (n=56, plus 56 spiked samples) are depicted. Comparisons between the enzymatic method and HPLC (a and b) mice, (e and f) rats and the colorimetric method and HPLC (c and d) mice, (g and h) rats are shown in this figure, whereas the comparison between the enzymatic and colorimetric method is added as Supplementary Material. In the Bland–Altman plots the middle line indicates the mean difference; the outer lines indicate the limits of agreement (mean±2s.d.). Calibration curves for HPLC were for mice: y=0.0654x+0.0187, r2=0.9981, and rats: y=0.0654x–0.0335, r2=0.994. Figure 1 continued on the following page. Kidney International 2007 71, 74-78DOI: (10.1038/sj.ki.5001988) Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 1 Method comparison of creatinine measurement in mouse and rat plasma. Comparison of HPLC, enzymatic, and colorimetric method in (a–d) mice and (e–h) rats. (a, c, e, and g) scatter plots with regression line (solid), line of identity (broken), regression equation, and coefficient of determination (r2) as well as (b, d, f, h) Bland–Altman plots for the comparison of creatinine concentrations in spiked (0.4mg/dl creatinine added) and unspiked plasma of healthy as well as diseased mice (n=61, plus 61 spiked samples) and rats (n=56, plus 56 spiked samples) are depicted. Comparisons between the enzymatic method and HPLC (a and b) mice, (e and f) rats and the colorimetric method and HPLC (c and d) mice, (g and h) rats are shown in this figure, whereas the comparison between the enzymatic and colorimetric method is added as Supplementary Material. In the Bland–Altman plots the middle line indicates the mean difference; the outer lines indicate the limits of agreement (mean±2s.d.). Calibration curves for HPLC were for mice: y=0.0654x+0.0187, r2=0.9981, and rats: y=0.0654x–0.0335, r2=0.994. Figure 1 continued on the following page. Kidney International 2007 71, 74-78DOI: (10.1038/sj.ki.5001988) Copyright © 2007 International Society of Nephrology Terms and Conditions