Figure 1. Chemical structures of paeoniflorin and hyperoside.

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Figure 1. Chemical structures of paeoniflorin and hyperoside. From: Determination of Paeoniflorin in Rat Plasma by Ultra-high Performance Liquid Chromatography-Tandem Mass Spectrometry and its Application to a Pharmacokinetic Study J Chromatogr Sci. 2017;55(10):1006-1012. doi:10.1093/chromsci/bmx066 J Chromatogr Sci | © Crown copyright 2017.This article contains public sector information licensed under the Open Government Licence v3.0 (http://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/).

Figure 2. Full-scan product ion mass spectra of [M + HCOOH-H]<sup>−</sup> ion and fragmentation pathway for paeoniflorin (A) and [M-H]<sup>−</sup> ion for hyperoside (B). From: Determination of Paeoniflorin in Rat Plasma by Ultra-high Performance Liquid Chromatography-Tandem Mass Spectrometry and its Application to a Pharmacokinetic Study J Chromatogr Sci. 2017;55(10):1006-1012. doi:10.1093/chromsci/bmx066 J Chromatogr Sci | © Crown copyright 2017.This article contains public sector information licensed under the Open Government Licence v3.0 (http://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/).

Figure 3. Chromatograms of paeoniflorin and IS Figure 3. Chromatograms of paeoniflorin and IS. Top, a blank rat plasma sample; middle, a blank plasma spiked with paeoniflorin (1.6 μg/mL) and IS (1.98 μg/mL); bottom, a rat plasma sample after an oral administration of BC (0.675 g/kg) at intervals of 2 h. From: Determination of Paeoniflorin in Rat Plasma by Ultra-high Performance Liquid Chromatography-Tandem Mass Spectrometry and its Application to a Pharmacokinetic Study J Chromatogr Sci. 2017;55(10):1006-1012. doi:10.1093/chromsci/bmx066 J Chromatogr Sci | © Crown copyright 2017.This article contains public sector information licensed under the Open Government Licence v3.0 (http://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/).

Figure 4. Plasma concentration–time profile of paeoniflorin after an oral administration of 0.675 g/kg BC in rats (n = 8). From: Determination of Paeoniflorin in Rat Plasma by Ultra-high Performance Liquid Chromatography-Tandem Mass Spectrometry and its Application to a Pharmacokinetic Study J Chromatogr Sci. 2017;55(10):1006-1012. doi:10.1093/chromsci/bmx066 J Chromatogr Sci | © Crown copyright 2017.This article contains public sector information licensed under the Open Government Licence v3.0 (http://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/).