Treatment of Leptomeningeal Metastases in a Patient with Non-Small Cell Lung Cancer Harboring EGFR T790M Mutation - DOI:10.1159/000480452 Fig. 1. a Brain.

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Treatment of Leptomeningeal Metastases in a Patient with Non-Small Cell Lung Cancer Harboring EGFR T790M Mutation - DOI:10.1159/000480452 Fig. 1. a Brain MRI (2/2/2016): post-contrast T1 fat suppressed images demonstrating extensive leptomeningeal carcinomatosis throughout the cerebellar folia in a pattern classically described as “Zuckerguss” or sugar icing (arrow). b Brain MRI (10/31/2016): post-contrast T1 fat suppressed images after the administration of osimertinib demonstrating marked reduction of leptomeningeal enhancement of the cerebellar folia consistent with treatment response. The Author(s). Published by S. Karger AG, Basel - CC BY-NC 4.0