Swiss PDB Viewer (SPDBV) program

Slides:



Advertisements
Similar presentations
CCP4 Molecular Graphics (CCP4MG)
Advertisements

Molecular interactions Non-covalent interactions are key to understanding the behavior of biological molecules. So just by way of introduction, I wanted.
Protein Primer. Outline n Protein representations n Structure of Proteins Structure of Proteins –Primary: amino acid sequence –Secondary:  -helices &
Speed of Gases. Speed of Gases Root Mean Square Speed of Gases R = J *K / mol J = 1kg * m2 / s2 MM = molar mass.
Molecular Docking Using GOLD Tommi Suvitaival Seppo Virtanen S Basics for Biosystems of the Cell Fall 2006.
2.4 Intermolecular Forces
Computational Structure Prediction Kevin Drew BCH364C/391L Systems Biology/Bioinformatics 2/12/15.
Tutorials for protein data bank and swiss PDB viewer 2010/04/19 Prof. Jinn-Moon Yang Yen-Fu Chen and Kai-Cheng Hsu
Chapter 22, Macromolecules and aggregates Ideality and reality Simplicity of small systems and complexity of real systems Entropy and order Dealing with.
Protein Structure Modelling Many sequences - few structures Homology Modelling - Based on Sequence Similarity with Sequences of Known Structures.
Molecular visualization
Parts of an Atom. What is an atom? Atoms are the fundamental building blocks of all things Atoms are the most basic unit of matter Atoms contain three.
On the binding affinity of macromolecular interactions: daring to ask why proteins interact by Panagiotis L. Kastritis, and Alexandre M. J. J. Bonvin Interface.
Enzymes In Depth With pH!. pH Enzymes Globular proteins Built from amino acids that have acidic and basic characteristics – Amino acids have both.
10/3/2003 Molecular and Cellular Modeling 10/3/2003 Introduction Objective: to construct a comprehensive simulation software system for the computational.
Covalent interactions non-covalent interactions + = structural stability of (bio)polymers in the operative molecular environment 1 Energy, entropy and.
Introduction and Review Aj. Pikulthong Chaimongkol.
Protein Structure Prediction: Homology Modeling & Threading/Fold Recognition D. Mohanty NII, New Delhi.
Manipulation of fullerenes on graphene by modification of the atomic structure.
Standard Deviation A Measure of Variation in a set of Data.
1.  Introduction  STARTING a SPDB view Session  Basic SPDB view Commands  Advanced SPDB view Commands  Ending a SPDB view Session 2.
8.4 The Kinetic Molecular Theory and Real Gas Behavior.
14.0 Math Review 14.1 Using a Calculator Calculator
Computational Structure Prediction
Fig. 9. Scatter plots of 500 inferred rates versus their simulated values with a model tree with six sequences and d = 0.1 for (a) ML and (b) EB-EXP. The.
25 Math Review Part 1 Using a Calculator
Protein Classification
Square Roots Practice © T Madas.
Protein Structure Prediction and Protein Homology modeling
Ionic and Metallic Bonding
Liquids, Solids and Intermolecular Forces Suroviec Spring 2015
Volume 10, Issue 5, Pages (November 2002)
Conformation Dependence of Backbone Geometry in Proteins
I. Intermolecular Forces
1. Pure Protein (0.3 mL, mM; ~ 10 mg)
AP Chemistry Chemistry Basics.
RM 2 7 +RM 2 4 RM 7 3 +RM 1 6 RM 5 2 +RM 2 4 RM 1 3 +RM5 2.
Intermolecular Forces
Biochemistry: Chemistry Basics
Intermolecular Forces
Biochemistry: Chemistry Basics
No calculators allowed
Modular Recognition of RNA by a Human Pumilio-Homology Domain
Volume 18, Issue 11, Pages (November 2010)
Barley lipid-transfer protein complexed with palmitoyl CoA: the structure reveals a hydrophobic binding site that can expand to fit both large and small.
Volume 13, Issue 4, Pages (February 2004)
Boiling Point Determination
Molecular Dynamics of a Protein Surface: Ion-Residues Interactions
The 1.9 Å Structure of α-N-Acetylgalactosaminidase
An Atomic Model of the Interferon-β Enhanceosome
Conservation of Protein Structure over Four Billion Years
AP Chemistry Chemistry Basics.
The basis for K-Ras4B binding specificity to protein farnesyl-transferase revealed by 2 Å resolution ternary complex structures  Stephen B Long, Patrick.
Crystal Structure of a Phosphoinositide Phosphatase, MTMR2
Chemical Context of Life
AP Chemistry Chemistry Basics.
Warm Up 10/26: What are 3 reasons that lactase is used for industrial purposes? Will lactase act on fructose? Why or why not? Is lactose a monosaccharide,
Biochemistry: Chemistry Basics
Biochemistry: Chemistry Basics
Molecular Therapy - Nucleic Acids
Fig. 6 Covalent inhibition of tuberculosis target MptpB.
Gydo C.P. van Zundert, Adrien S.J. Melquiond, Alexandre M.J.J. Bonvin 
Biochemistry: Chemistry Basics
Biochemistry: Chemistry Basics
Mr.Halavath Ramesh 16-MCH-001 Dept. of Chemistry Loyola College University of Madras-Chennai.
Mr.Halavath Ramesh 16-MCH-001 Dept. of Chemistry Loyola College University of Madras-Chennai.
Mr.Halavath Ramesh 16-MCH-001 Dept. of Chemistry Loyola College University of Madras-Chennai.
Mr.Halavath Ramesh 16-MCH-001 Dept. of Chemistry Loyola College University of Madras-Chennai.
Tertiary structure of an immunoglobulin-like domain from the giant muscle protein titin: a new member of the I set  Mark Pfuhl, Annalisa Pastore  Structure 
Presentation transcript:

Swiss PDB Viewer (SPDBV) program We will do the following tasks: Displaying the protein in the 3D ribbon form. Energy minimization of the protein model. Site directed mutagenesis in the protein model. Displaying the Ramachandran plot and validate the protein model. Displaying Van der Waals surface, accessible surface and molecular surface of the protein model. Compute Hydrogen bonding and displaying it’s lengths. Superimposing two protein models (fitting and calculate Root Mean Square difference RMS).

Displaying the protein in the 3D ribbon form. First task: Displaying the protein in the 3D ribbon form.

Energy minimization of the protein model. Second task: Energy minimization of the protein model.