From: Orbital Volume Augmentation After Injection of Human Orbital Adipose-Derived Stem Cells in Rabbits Invest. Ophthalmol. Vis. Sci.. 2013;54(4):2410-2416.

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From: Orbital Volume Augmentation After Injection of Human Orbital Adipose-Derived Stem Cells in Rabbits Invest. Ophthalmol. Vis. Sci.. 2013;54(4):2410-2416. doi:10.1167/iovs.12-11210 Figure Legend: Sequential histologic findings in adipose tissue after injection with HAG only, HAG + hoSVF, or HAG + hoADSCs using hematoxylin and eosin staining. (A) Four weeks after HAG only injection, subacute severe inflammation is seen in the rabbit orbital fat. Injected HAG is seen as a basophilic molecule. (B) At 4 weeks after HAG + hoSVF injection, subacute moderate inflammation is seen. (C) At 4 weeks after HAG + hoADSCs injection, severe inflammation is seen in (A) and (B). HAG molecules are visible between the orbital adipose tissue of the rabbit. (D) At 6 weeks after HAG only injection, inflammation is moderate compared to that at 4 weeks (A). (E) At 6 weeks after HAG + hoSVF injection, fibrosis with collagen formation is seen, and inflammation is less than at 4 weeks (B). (F) At 8 weeks after HAG + hoADSCs injection, the findings are similar to those in (E). (G) At 12 weeks after HAG + hoSVF injection, inflammation has disappeared, and mature fibrosis is observed. (H) At 12 weeks after HAG + hoADSCs injection, inflammation has disappeared, and fibrosis is observed. Thus, volume augmentation was achieved, and no tumor formation was observed in the rabbit orbits. All images are ×100 magnification. Date of download: 11/15/2017 The Association for Research in Vision and Ophthalmology Copyright © 2017. All rights reserved.