Antigen-processing pathways

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Antigen-processing pathways Antigen-processing pathways. The intracellular antigen-processing pathways for major histocompatibility complex (MHC) class I, MHC class II, and CD1 presentation are shown. The MHC class I pathway involves the processing of cytoplasmic proteins, whereas the MHC class II pathway involves the processing of exogenous proteins. The CD1 pathway regulates the processing and presentation of self-glycosphingolipids and bacterial lipoglycans. DN T cell = double-negative (CD4−/CD8−) T cell; ER = endoplasmic reticulum; MIIC = MHC class II lysosomal peptide-loading compartment; NKT cell = natural killer T cell; TAP = transporter associated with antigen processing; TCR = T-cell receptor. Source: Chapter 10. Innate and Adaptive Immunity in the Skin, Fitzpatrick's Dermatology in General Medicine, 8e Citation: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, Wolff K. Fitzpatrick's Dermatology in General Medicine, 8e; 2012 Available at: http://accessmedicine.mhmedical.com/DownloadImage.aspx?image=/data/books/gold8/gold8_c010f005.png&sec=41139994&BookID=392&ChapterSecID=41138705&imagename= Accessed: November 15, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved