CZ5226: Advanced Bioinformatics Lecture 3: MHC Molecules Prof CZ5226: Advanced Bioinformatics Lecture 3: MHC Molecules Prof. Chen Yu Zong Tel: 6874-6877 Email: csccyz@nus.edu.sg http://xin.cz3.nus.edu.sg Room 07-24, level 7, SOC1, National University of Singapore
MHC in Immune System
MHC in Immune System
MHC in Immune System
MHC in Immune System
MHC in Immune System
MHC in Immune System
T-Cell Recognition of Peptide Antigen through MHC-peptide complex
T-Cell Recognition of Allogeneic MHC
Classes of MHC
Antigen capture and display
Antigen capture and display
Cross Presentation of Antigens
MHC Genes
MHC Genes
MHC Genes
Properties of MHC genes
Properties of MHC genes
Properties of MHC Genes
Properties of MHC Genes
Properties of MHC Genes
Structure of MHC
MHC Gene and Protein Structure
MHC protein structure
MHC protein structure
Peptide Binding to MHC
Peptide Binding to MHC
MHC-peptide structure
MHC-peptide structure
Peptide Binding to MHC
Peptide Binding to MHC
Peptide Binding to MHC
Peptide Binding to MHC
Peptide Binding to MHC
MHC and Diseases
MHC and Diseases
Summary of MHC MHC-I consist of an alpha chain and beta-2 microglobulin and present endogenous peptides to T lymphocytes, which are processed by the cytosolic pathway in APC. MHC-II have alpha and beta chains and present to T cells exogenous peptides processed by the endocytic pathway. Non-classical MHC are involved in antigen processing, presentation and tolerance induction. Minor H antigens are genetic variants of peptides presented by MHC to T cells and cause graft rejection and graft versus host reaction. HLA has an association with autoimmune disease due to its capacity of altering antigen presentation and clearance, lympocyte activation and tolerance induction.
Summary of Today’s lecture Adaptive immune system Comparison between innate and adaptive immune system Relevant cells and related molecules