Volume 111, Issue 1, Pages 71-77 (January 2011) Antimicrobial photodynamic therapy in rat experimental candidiasis: evaluation of pathogenicity factors of Candida albicans  Joyce da Silva Martins, MD, Juliana Campos Junqueira, MD, PhD, Raquel Lourdes Faria, Naiara Fonseca Santiago, Rodnei Dennis Rossoni, Carlos Eduardo Dias Colombo, MD, PhD, Antonio Olavo Cardoso Jorge, MD, PhD  Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics  Volume 111, Issue 1, Pages 71-77 (January 2011) DOI: 10.1016/j.tripleo.2010.08.012 Copyright © 2011 Mosby, Inc. Terms and Conditions

Fig. 1 Study design. L+P−: treated with laser and photosensitizer; L+P−: treated with laser only; L−P+: treated with photosensitizer only; L−P−: control group. CFU, colony-forming units. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics 2011 111, 71-77DOI: (10.1016/j.tripleo.2010.08.012) Copyright © 2011 Mosby, Inc. Terms and Conditions

Fig. 2 Means and SDs of the colony-forming units (CFU) per mL of Candida albicans recovered from the oral cavity of the rats before and after the experimental treatment. There was no significant difference between the groups L+P+, L+P−, L−P+, and L−P− (P = .106). Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics 2011 111, 71-77DOI: (10.1016/j.tripleo.2010.08.012) Copyright © 2011 Mosby, Inc. Terms and Conditions

Fig. 3 Means and SDs of the precipitation zone (Pz) value for enzymatic activity of phospholipase and proteinase. *Significant difference between the groups L+P+ and L−P+ for proteinase activity (P = .018). Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics 2011 111, 71-77DOI: (10.1016/j.tripleo.2010.08.012) Copyright © 2011 Mosby, Inc. Terms and Conditions

Fig. 4 Sagittal section of the tongue dorsum of a rat from the L−P− group. Tissue lesion characterized by loss of filiform papillae, epithelial hyperplasia (diamonds) and hyperparakeratosis (arrow). hematoxylin-eosin; original magnification ×200. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics 2011 111, 71-77DOI: (10.1016/j.tripleo.2010.08.012) Copyright © 2011 Mosby, Inc. Terms and Conditions

Fig. 5 Numbers and medians of epithelial lesions observed in the histologic analyses of the tongue dorsum. Different letters represent significant difference between the groups: L+P+ and L+P− (P = .007), L+P+ and L−P+ (P = 0011), and L+P+ and L−P− (P = .001). Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics 2011 111, 71-77DOI: (10.1016/j.tripleo.2010.08.012) Copyright © 2011 Mosby, Inc. Terms and Conditions