The renin-angiotensin-aldosterone system

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The renin-angiotensin-aldosterone system The renin-angiotensin-aldosterone system. Renin produced by the kidney hydrolyzes angiotensinogen secreted by the liver into a decapeptide, angiotensin I. Under the effects of a converting enzyme in the lungs, angiotensin I is transformed into an octapeptide, angiotensin II. In itself, angiotensin II has vasoconstrictive properties, but it also binds to a membrane receptor of the cells of the zona glomerulosa of the adrenal cortex in order to activate the secretion of aldosterone. (From Migeon and Donohoue.322 Used by permission from Charles C Thomas.) Source: Congenital Adrenal Hyperplasia, The Online Metabolic and Molecular Bases of Inherited Disease Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: http://ommbid.mhmedical.com/DownloadImage.aspx?image=/data/books/971/ch159fg7.png&sec=62647633&BookID=971&ChapterSecID=62647583&imagename= Accessed: November 22, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved