Diagram representing the renin–angiotensin–aldosterone system

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Diagram representing the renin–angiotensin–aldosterone system Diagram representing the renin–angiotensin–aldosterone system. The interrelationship between the kidney, angiotensin II, and regulation of blood pressure is depicted. Renin secretion from the juxtaglomerular cells in the afferent arterioles is regulated by three major factors to trigger conversion of angiotensinogen to angiotensin 1. The primary sites of action for major antihypertensive agents are included: ① ACE inhibitors; ② angiotensin II receptor blockers; ③ β-blockers; ④ calcium channel blockers; ⑤ diuretics; ⑥ aldosterone antagonists; ⑦ direct renin inhibitor. Source: Chapter 3. Hypertension, Pharmacotherapy: A Pathophysiologic Approach, 9e Citation: DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey L. Pharmacotherapy: A Pathophysiologic Approach, 9e; 2014 Available at: https://accesspharmacy.mhmedical.com/DownloadImage.aspx?image=/data/books/dipi9/dipi9_c003f001.png&sec=48819648&BookID=689&ChapterSecID=48811453&imagename= Accessed: November 22, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved