Relevance of specific IgE antibody titer to the prevalence, severity, and persistence of asthma among 19-year-olds in northern Sweden Matthew S. Perzanowski,

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Relevance of specific IgE antibody titer to the prevalence, severity, and persistence of asthma among 19-year-olds in northern Sweden Matthew S. Perzanowski, PhD, Eva Ronmark, PhD, Hayley R. James, BS, Linnea Hedman, PhD, Alexander J. Schuyler, BS, BA, Anders Bjerg, MD, PhD, Bo Lundback, MD, Thomas A.E. Platts-Mills, MD, PhD, FRS Journal of Allergy and Clinical Immunology Volume 138, Issue 6, Pages 1582-1590 (December 2016) DOI: 10.1016/j.jaci.2016.05.017 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Probability of wheeze related to the titer of IgE antibodies specific for cat dander, dog dander, dust mite, or birch pollen. Unadjusted logistic regression lines are depicted, with 95% CIs in gray. P < .001, P < .001, P = .17, and P < .001 for cat dander, dog dander, dust mite, and birch pollen, respectively. Journal of Allergy and Clinical Immunology 2016 138, 1582-1590DOI: (10.1016/j.jaci.2016.05.017) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Relationship between IgE antibodies to any mammal and asthma severity assessed by frequency of wheezing attacks per year (A) or medication use (B). The number of subjects in each of the 7 groups shown was as follows: 716 for negative results and 30, 63, 80, 40, 15, and 19 for each of the groups from 0.35 to 100 IU/mL. By using the χ2 test for trend, the P value was less than .001 for wheezing attacks or medication use. Journal of Allergy and Clinical Immunology 2016 138, 1582-1590DOI: (10.1016/j.jaci.2016.05.017) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 A, Relationship between sensitization and asthma diagnosis among patients with persistent asthma (n = 68), late-onset asthma (n = 63), and no reported asthma (n = 672). B, The same analysis for patients with current asthma, which was persistent (n = 50) or late onset (n = 38), or no reported asthma (n = 672). For each group, the prevalence of sensitization is shown for any allergen (≥0.35 IU/mL), any mammalian allergen, high-titer mammalian allergen (≥17.5 IU/mL), or no sensitization. Journal of Allergy and Clinical Immunology 2016 138, 1582-1590DOI: (10.1016/j.jaci.2016.05.017) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Relationship between IgG specific for Fel d 1 and cat ownership. Both low-titer (150-500 U/mL) and high-titer (>500 U/mL) IgE were significantly high among cat owners (n = 279) (**P < .01). By contrast, any IgE to cat dander was less common among cat owners (*P < .05). The approximate range of cat allergen exposure is shown for cat owners and non–cat owners (n = 684).31 Journal of Allergy and Clinical Immunology 2016 138, 1582-1590DOI: (10.1016/j.jaci.2016.05.017) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1A Journal of Allergy and Clinical Immunology 2016 138, 1582-1590DOI: (10.1016/j.jaci.2016.05.017) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1B Journal of Allergy and Clinical Immunology 2016 138, 1582-1590DOI: (10.1016/j.jaci.2016.05.017) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1C Journal of Allergy and Clinical Immunology 2016 138, 1582-1590DOI: (10.1016/j.jaci.2016.05.017) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1D Journal of Allergy and Clinical Immunology 2016 138, 1582-1590DOI: (10.1016/j.jaci.2016.05.017) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2A Journal of Allergy and Clinical Immunology 2016 138, 1582-1590DOI: (10.1016/j.jaci.2016.05.017) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2B Journal of Allergy and Clinical Immunology 2016 138, 1582-1590DOI: (10.1016/j.jaci.2016.05.017) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Journal of Allergy and Clinical Immunology 2016 138, 1582-1590DOI: (10.1016/j.jaci.2016.05.017) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions