Volume 148, Issue 1, Pages 159-168 (July 2015) Differential Effect of Modified Medical Research Council Dyspnea, COPD Assessment Test, and Clinical COPD Questionnaire for Symptoms Evaluation Within the New GOLD Staging and Mortality in COPD  Ciro Casanova, MD, Jose M. Marin, MD, Cristina Martinez-Gonzalez, MD, Pilar de Lucas-Ramos, MD, Isabel Mir-Viladrich, MD, Borja Cosio, MD, German Peces-Barba, MD, Ingrid Solanes-García, MD, Ramón Agüero, MD, Nuria Feu-Collado, MD, Miryam Calle-Rubio, MD, Inmaculada Alfageme, MD, Alfredo de Diego-Damia, MD, Rosa Irigaray, MD, Margarita Marín, MD, Eva Balcells, MD, Antonia Llunell, MD, Juan Bautista Galdiz, MD, Rafael Golpe, MD, Celia Lacarcel, MD, Carlos Cabrera, MD, Alicia Marin, MD, Joan B. Soriano, MD, Jose Luis Lopez-Campos, MD, Juan José Soler-Cataluña, MD, Juan P. de-Torres, MD  CHEST  Volume 148, Issue 1, Pages 159-168 (July 2015) DOI: 10.1378/chest.14-2449 Copyright © 2015 The American College of Chest Physicians Terms and Conditions

Figure 1 Comparative type 2 receiver operating characteristic curves for the CAT, the CCQ, and the mMRC dyspnea score, with all-cause mortality as the main outcome in patients with COPD. CAT = COPD Assessment Test; CCQ = Clinical COPD Questionnaire; mMRC = modified Medical Research Council. CHEST 2015 148, 159-168DOI: (10.1378/chest.14-2449) Copyright © 2015 The American College of Chest Physicians Terms and Conditions

Figure 2 A-C, Kaplan-Meier curves for all-cause mortality using symptom-evaluating tools and cutoff proposed by GOLD (Global Initiative for Chronic Obstructive Lung Disease): A, CAT ≥ 10; B, CCQ > 1; C, mMRC dyspnea ≥ 2. The survival differed significantly between groups (P = .001) only when the mMRC dyspnea threshold was used. See Figure 1 legend for expansion of other abbreviations. CHEST 2015 148, 159-168DOI: (10.1378/chest.14-2449) Copyright © 2015 The American College of Chest Physicians Terms and Conditions

Figure 3 A, B, Kaplan-Meier curves for all-cause mortality using symptom-evaluating tools by GOLD with the new cutoff that have demonstrated to predict all-causes mortality: A, CAT ≥ 17; B, CCQ > 2.5. See Figure 1 and 2 legends for expansion of abbreviations. CHEST 2015 148, 159-168DOI: (10.1378/chest.14-2449) Copyright © 2015 The American College of Chest Physicians Terms and Conditions

Figure 4 A-C, Kaplan-Meier curves for all-cause mortality in the ABCD GOLD classification using symptom-evaluating tools with the new thresholds proposed in this study: A, CAT ≥ 17; B, CCQ > 2.5; C, mMRC dyspnea ≥ 2. See Figure 1 and 2 legends for expansion of abbreviations. CHEST 2015 148, 159-168DOI: (10.1378/chest.14-2449) Copyright © 2015 The American College of Chest Physicians Terms and Conditions