Opioid-Induced Bowel Dysfunction

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Presentation transcript:

Opioid-Induced Bowel Dysfunction Jay Thomas, MD, PhD Journal of Pain and Symptom Management Volume 35, Issue 1, Pages 103-113 (January 2008) DOI: 10.1016/j.jpainsymman.2007.01.017 Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 1 Anatomy of the GI system (adapted from: Shetzline and Liddle 20025). Journal of Pain and Symptom Management 2008 35, 103-113DOI: (10.1016/j.jpainsymman.2007.01.017) Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 2 ICC interactions (LM=longitudinal muscle; CM=circular muscle; ICMP=myenteric plexus interstitial cells; ICIM=intramuscular interstitial cells; ICSM=submucosal interstitial cells) (adapted from: Cook and Brookes, 20027). Journal of Pain and Symptom Management 2008 35, 103-113DOI: (10.1016/j.jpainsymman.2007.01.017) Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 3 Chemical structure of alvimopan. Journal of Pain and Symptom Management 2008 35, 103-113DOI: (10.1016/j.jpainsymman.2007.01.017) Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 4 Chemical structure of methylnaltrexone. Journal of Pain and Symptom Management 2008 35, 103-113DOI: (10.1016/j.jpainsymman.2007.01.017) Copyright © 2008 U.S. Cancer Pain Relief Committee Terms and Conditions