Alzheimer’s disease core biomarkers and prediction of dementia in MCI: The effect of age at onset  Anna Caroli, Samantha Galluzzi, Clarissa Ferrari, Annapaola Prestia, Wiesje M. van der Flier, Rik Ossenkoppele, Bart N.M. van Berckel, Frederik Barkhof, Charlotte E. Teunissen, Anders Wall, Stephen F. Carter, Michael Scholl, Il Han Choo, Timo Grimmer, Alberto Redolfi, Agneta Nordberg, Philip Scheltens, Alexander Drzezga, Giovanni Battista Frisoni  Alzheimer's & Dementia: The Journal of the Alzheimer's Association  Volume 11, Issue 7, Pages P140-P142 (July 2015) DOI: 10.1016/j.jalz.2015.07.064 Copyright © 2015 Terms and Conditions

Figure 1 Survival curves displaying the association of biomarker abnormality with progression to AD dementia by age at onset in MCI patients. Patients with normal and abnormal biomarkers are denoted by dashed and solid lines, respectively. + indicates censored cases. HR: unadjusted hazard ratio (95% confidence interval) in Cox regression models. The most predictive individual biomarker is FDG PET, with no difference between earlier and later onset groups. Hippocampal volume is also predictive in both groups, but predictivity is lower. CSF Ab42 is predictive in earlier but not in later onset patients. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2015 11, P140-P142DOI: (10.1016/j.jalz.2015.07.064) Copyright © 2015 Terms and Conditions

Figure 2 Receiver operating characteristic curves showing prognostic performance (discrimination of pMCI from siMCI) of biomarkers. Values denote areas under the curve (95% confidence interval). The analysis confirms the findings of Figure 1. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2015 11, P140-P142DOI: (10.1016/j.jalz.2015.07.064) Copyright © 2015 Terms and Conditions

Figure 3 Receiver operating characteristic curves showing the prognostic performance of composite mdices computed in logistic models including biomarkers with significant effect (earlier onset: Aβ42, FDGPET, and hippocampal volume; later onset: FDG-PET and hippocampal volume). Biomarkers were included in the model as continuous variables. Values denote areas under the curve (95% confidence interval). The two curves were not significantly different. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2015 11, P140-P142DOI: (10.1016/j.jalz.2015.07.064) Copyright © 2015 Terms and Conditions