Regulation of osteoblast (A) and osteoclast (B) development

Slides:



Advertisements
Similar presentations
Chapter 62 Chapter 62 Mechanisms of Bone Destruction in Myeloma Copyright © 2013 Elsevier Inc. All rights reserved.
Advertisements

Chapter 12 Chapter 12 Parathyroid Hormone and Parathyroid Hormone-Related Protein Copyright © 2013 Elsevier Inc. All rights reserved.
Regulation of calcitonin secretion Elevation of blood calcium –Response greater in male –Affected by age Declines as one ages Secretion by GI tract –Gastrin.
BIOCHEMISTRY BONE METABOLISM MSK BLOCK SYSTEM Nabil Bashir October 1 st, 2009.
PTH Calcitonin 10mg% Vitamin D Lecture 52 Ca++ Homeostasis
Bone maintenance, repair, and physiology. A. Bone remodeling
New insights into role of microenvironment in multiple myeloma. B
Immune pathogenesis of apoptosis of CD34 multipotential hematopoietic cells in acquired aplastic anemia. Antigens are presented to T lymphocytes by antigen-presenting.
Follicular lymphoma. The normal nodal architecture is effaced by nodular expansions of tumor cells. Nodules vary in size and contain predominantly small.
The JAK-STAT signaling system represents a series of reactions that take place when a hormone binds a receptor that uses this system. While the hormone.
Pathogenesis of bone diseases in chronic kidney disease
The hypothalamic-pituitary-adrenal axis
Modification of the trade-off hypothesis of Slatopolsky and Bricker as it relates to the adaptation of the body to decreased functional renal mass in an.
Vane anemometer. (Reproduced with permission from Morgan GE, Mikhail MS, Murray MJ. Clinical Anesthesiology. 4th ed. New York, NY: McGraw-Hill; Figure.
Algorithm for diagnostic fasting study
Evaluation of hypothyroidism
Evaluation of hypothyroidism
Algorithm of the approach to the diagnosis and treatment of children with fractures due to osteoporosis. BMD, bone mineral density; GC, glucocorticoids;
Ochronotic pigmentation of the femur of a 56-year-old alkaptonuric patient. (Courtesy of Dr. H. W. Edmonds of the Washington Hospital Center, Washington,
Schematic representation of the autonomic nervous system
(A) Pathway of vitamin D metabolism
Abbreviations: COX-2, cyclooxygenase-2; Gpx3, glutathione peroxidase 3; IGF, insulin-like growth factor; IKK, I kappa B kinase; IκBα, inhibitor of kappa.
A: High female anatomic anomaly. Low vaginal fistula
Changes in the ovarian follicle, endometrial thickness, and serum hormone levels during a 28-day menstrual cycle. P, progesterone; E2, estradiol; LH, luteinizing.
Potential mechanisms of drug-induced liver injury
Scurvy (vitamin C deficiency)
Synthesis of calcitriol
Effects of active metabolites of vitamin D (D), parathyroid hormone (PTH), calcitonin (CT), and fibroblast growth factor 23 (FGF23) on calcium and phosphorus.
Calcium balance and fluxes in a normal human
(Reproduced with permission from Amato AA, Russell JA
Nutrient or ion regulation of hormone release
Regulation of gating in ion channels
(Modified from Conlin PR, et al
Vasopressin secretion in response to osmotic and nonosmotic stimuli
Relationship of glycemic control and diabetes duration to diabetic retinopathy. The progression of retinopathy in individuals in the Diabetes Control and.
The processing of microRNA that is involved in gene regulation by RNA interference. (Reprinted with permission from Brooker RJ: Genetics: Analysis & Principles,
Negative feedback regulation of parathyroid hormone (PTH) release
Estimated number of AIDS cases and AIDS deaths, United States, 1985–2011. (From CDC.) Source: Human Immunodeficiency Virus Disease: AIDS and Related Disorders,
The GHRH/GH/IGF-1 system
Cystic fibrosis with bronchiectasis, apical disease.
Effects of PTH and 1,25-dihydroxycholecalciferol on whole body calcium homeostasis. A reduction in plasma calcium stimulates parathyroid hormone secretion.
Synthesis and activation of vitamin D (cholecalciferol)
This diagram outlines the key mechanisms by which calcineurin (Cn) inhibitors and mammalian target of rapamycin (mTOR) inhibitors inhibit T-cell activation.
Radioiodine scintigraphy of a patient with thyroid cancer shows abnormal 123I uptake in the neck and chest corresponding to iodine-avid metastases in the.
Hormones of the adrenal cortex
Sites of action of hematopoietic growth factors in the differentiation and maturation of marrow cell lines. A self-sustaining pool of marrow stem cells.
The potential role of follicle-stimulating hormone in the cardiovascular, metabolic, skeletal, and cognitive effects associated with androgen deprivation.
Myeloma cell interaction with extracellular matrix (ECM) and accessory cells in the marrow. Myeloma cells require support from bone marrow stromal cells.
Figure 2 Functional model of enthesitis
Vitamin D and the Parenteral Nutrition Patient
Agents That Affect Bone Mineral Homeostasis
Bone remodeling Lining cells Bone marrow.
Volume 17, Issue 5, Pages (May 2013)
The Gutsy Side of Bone Cell Metabolism
How do cells talk to each other
Figure 2 Main functions of IL-1
Figure 4 Osteocyte regulation of bone formation and resorption
Pathogenesis of calciphylaxis: Hans Selye to nuclear factor κ-B
Volume 151, Issue 4, Pages (October 2016)
Craig H Selzman, MD, Stephanie A Miller, MD, Alden H Harken, MD 
Chapter 65 - The Hormonal Regulation of Calcium Metabolism
Pathophysiology of Bone Metastases in Prostate Cancer
Cell biology of the osteoclast
Holger Lawall, MD, Peter Bramlage, MD, PhD, Berthold Amann, MD 
The Dual Role of Bone Morphogenetic Proteins in Cancer
Lec.9 Cytokines.
Figure 1 The role of macrophages in RA
Protein nutrition as therapy for a genetic disorder of bone?
Bisphosphonate Use in Patients with Lung Cancer and Bone Metastases: Recommendations of a European Expert Panel  Filippo De Marinis, MD, Wilfried Eberhardt,
Figure 1. Cross talk between the immune system and osteoclasts in osteoclastogenesis. Osteoclasts are derived from monocyte precursor cells. RANKL from.
Presentation transcript:

Regulation of osteoblast (A) and osteoclast (B) development Regulation of osteoblast (A) and osteoclast (B) development. Hormones, cytokines, and growth factors regulating cell proliferation and differentiation are shown above the arrows. Transcription factors regulating cell proliferation and differentiation are shown below the arrows. BMPs, bone morphogenic proteins; PTH, parathyroid hormone; Vit D, vitamin D; IGFs, insulin-like growth factors; CBFA1, core binding factor A1; M-CSF, macrophage colony-stimulating factor; PU-1, a monocyte- and B lymphocyte-specific ets family transcription factor; NFkB, nuclear factor kB; TRAF, tumor necrosis factor receptor-associated factors; RANK ligand, receptor activator of NFkB ligand; IL-1, interleukin 1; IL-6, interleukin 6. (Reproduced with permission from Jameson JL. Principles of endocrinology. In: Jameson JL, ed. Harrison’s Endocrinology. New York, NY: McGraw-Hill; 2006, Figure 23-1, p. 412.) Source: Disorders of Bone and Mineral Metabolism, Pediatric Practice: Endocrinology, 2e Citation: Kappy MS, Allen DB, Geffner ME. Pediatric Practice: Endocrinology, 2e; 2013 Available at: https://accesspediatrics.mhmedical.com/DownloadImage.aspx?image=/data/books/1082/kap_ch7_f005.png&sec=61463601&BookID=1082&ChapterSecID=61463542&imagename= Accessed: December 15, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved