Papilledema means optic disc edema from raised intracranial pressure Papilledema means optic disc edema from raised intracranial pressure. This young woman developed acute papilledema, with hemorrhages and cotton-wool spots, as a rare side effect of treatment with tetracycline for acne. Source: DISORDERS OF THE EYE, Harrison's Neurology in Clinical Medicine, 4e Citation: Hauser SL, Josephson S. Harrison's Neurology in Clinical Medicine, 4e; 2017 Available at: http://neurology.mhmedical.com/DownloadImage.aspx?image=/data/books/2207/hauserneuro4_ch25_f012-1.png&sec=169309149&BookID=2207&ChapterSecID=169309049&imagename= Accessed: December 15, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved