Tiny RNA with great effects: miR-155 in alcoholic liver disease Phillipp Hartmann, Frank Tacke  Journal of Hepatology  Volume 64, Issue 6, Pages 1214-1216 (June 2016) DOI: 10.1016/j.jhep.2016.02.039 Copyright © 2016 European Association for the Study of the Liver Terms and Conditions

Fig. 1 Proposed roles of microRNA-155 (miR-155) in alcoholic liver disease (ALD). In a mouse model of ALD, miR-155 was found to be upregulated in hepatocytes and liver macrophages (Kupffer cells). By comparing wild-type (WT) and miR-155-deficient (KO) mice, Bala and coworkers revealed a central functional role of miR-155 for controlling lipid metabolism in hepatocytes and pro-inflammatory (M1) polarization in macrophages, ultimately promoting steatosis, hepatitis and fibrosis. Journal of Hepatology 2016 64, 1214-1216DOI: (10.1016/j.jhep.2016.02.039) Copyright © 2016 European Association for the Study of the Liver Terms and Conditions