Mariam Zoulgami1, Laura Epure1, J.J. Moore2, L’Hocine Yahia1 A porous Calcium Phosphate based Bioceramic prepared by SHS method for guided bone regeneration Mariam Zoulgami1, Laura Epure1, J.J. Moore2, L’Hocine Yahia1 1.Biomedical Engineering Institute, Laboratory for the Inovation and Analysis of Bioperformance, École Polytechnique de Montréal, Canada 2. Center for Commercial Application of Combustion in space (CCACS), Colorado School of Mines, Colorado, USA Bioceramic and SHS Process Bioceramics and SHS method

Biomedical applications Orthopaedics Maxillo-facial and cranial surgeries Dentistry Bioceramic and SHS Process

Bioceramic and SHS Process Class of Bioceramics Resorbable bioactive ceramics Surface bioactive ceramics Bioinert ceramics HA (low crystaline) -TCP -TCP OCP TetCP DCPD HA/TCP Aragonite Coral etc… HA Bioglass® A-W glass Ceramics HA/Bioglass Al2O3/HA Al2O3/Bioglass Si3N4/Bioglass SiC/Bioglass ect… Al2O3 ZrO2 TiO2 SiC Si3N4 etc… Bioceramic and SHS Process

Bioceramic and SHS Process Functionality Bioactive ceramics Rapid proliferation of new bone Through Osteoconductive process Bioceramic and SHS Process

Ceramic powder methods Ceramic synthesis Solid-state Micro-wave method Ceramic process Combustion Synthesis Wet methods Sol-gel method  Hydrothermal method  Bioceramic and SHS Process

Bioceramic and SHS Process Bioceramics process Conventionnel methods Powder synthetis Powder compaction Drying Porogen Sintering (1100 ~1400 °C) Bioceramic and SHS Process

Self-propagating High temperature Synthesis (SHS) Mixing the reaction powders Powder compaction 1 2 Igniting the green pellet by exposing it to a heat source Propagation of combustion wave through the reactant mixture 3 4 Bioceramic and SHS Process

Advantages of the SHS technique Materials with better control of porosity Personalized implants Functionally graded materials Fast reactions Economic and simple process Bioceramic and SHS Process

Materials prepared by SHS process SHS method  good alternative Ceramics (e.g. Si3N4, Al2O3) Shape memory alloys (e.g. TiNi) High temperature intermetallic compounds Thin films and coatings (e.g. TiB2) Functionally-graded materials (e.g. TiC+Ni) Composite materials (e.g. TiC+Al2O3+Al) Bioceramic and SHS Process

The main challenge of the implant technology Our objective To use the SHS technique for developpment of new generation of implant materials with : Biological response Optimum of biodegradability Enhanced mechanical properties Bioceramic and SHS Process

Choice of bioceramic and parameters Β-TCP : Ca3(PO4)2 Parameters: pore diameter : 150 µm Φ  250 µm P1 = 150 µm P2 = 200 µm P3 = 250 µm pore volume : 60% Sample shape: cylinder (h = 20mm; D = 20mm) Bioceramic and SHS Process

Scanning Electron Microscopy-1- (x35) (x12) (x50) Bioceramic and SHS Process

Scanning Electron Microscopy-2- (x1000) (x25.000) Bioceramic and SHS Process

Characterization - diffraction RX β -TCP α –TCP Ca2P2O7 Bioceramic and SHS Process

Bioceramic and SHS Process MTT TEST Bioceramic and SHS Process

Conclusion & future prospects Originality of the method Better control of pore size and distribution Simple single step procedure Materials of high purity future prospects Functionally graded ceramics Biocombatibility and biodegradation investigations Mechanical properties studies Bioceramic and SHS Process

Bioceramic and SHS Process Thanks for the collaboration of & Bioceramic and SHS Process