Notch signaling and its emerging role in autoimmunity

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Presentation transcript:

Notch signaling and its emerging role in autoimmunity Tanapat PALAGA 1 ;Lisa M. MINTER 2, 3 ; 1. Department of Microbiology, Faculty of Science, Medical Microbiology Interdisciplinary Program, Graduate School, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand ; 2. Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA 01003, USA ; 3. Department of Veterinary & Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA ; Fig.3 Notch signaling in autoimmune diseases. Notch signaling has been implicated in various autoimmune conditions including systemic lupus erythematosus, rheumatoid arthritis, experimental autoimmune encephalomyelitismultiple sclerosis, immune thrombocytopenia purpura, and aplastic anemia. Increased or decreased expression of individual notch receptors andor ligands may be disease specific and, as such, may provide useful biomarkers of disease or targets for therapeutic intervention. See text for discussion of individual autoimmune conditions and notch receptorligand expression. Frontiers in Biology,2013,8(3),279-294. Doi:10.1007/s11515-012-1209-z