Cardiovascular effects and intraoperative pharmacokinetics of tramadol in sheep undergoing spinal surgery Giulia Maria De Benedictis, Mario Giorgi, Alice.

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Presentation transcript:

Cardiovascular effects and intraoperative pharmacokinetics of tramadol in sheep undergoing spinal surgery Giulia Maria De Benedictis, Mario Giorgi, Alice Depase, Virginia De Vito, Giorgia della Rocca, Luca Bellini Veterinary Anaesthesia and Analgesia Volume 44, Issue 5, Pages 1245-1252 (September 2017) DOI: 10.1016/j.vaa.2016.11.005 Copyright © 2017 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia Terms and Conditions

Figure 1 Trends over time for a) heart rate, b) systolic arterial pressure, c) mean arterial pressure and d) diastolic arterial pressure in sheep, which were administered tramadol intravenously at 4 mg kg−1 (T4) or 6 mg kg−1 (T6). Tramadol injection started at time 0; data are presented as mean±standard deviation. *Statistical difference versus time 0. Number between brackets indicated n<6. Veterinary Anaesthesia and Analgesia 2017 44, 1245-1252DOI: (10.1016/j.vaa.2016.11.005) Copyright © 2017 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia Terms and Conditions

Figure 2 Mean±standard deviation (bars) of plasma concentration (μg mL−1) over time of tramadol (circle) and M1 (square) in sheep administered tramadol intravenously at 4 mg kg−1 (group T4) or 6 mg kg−1 (group T6). Numbers between brackets indicate n<6. Veterinary Anaesthesia and Analgesia 2017 44, 1245-1252DOI: (10.1016/j.vaa.2016.11.005) Copyright © 2017 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia Terms and Conditions